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| * '''Description:''' part of the [[condensin]] complex, chromosomal origin condensation and segregation SMC protein <br/><br/>
| | {{#bank: Smc}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''smc''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ylqA ''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || yes {{PubMed|24440399,12682299}}
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| |style="background:#ABCDEF;" align="center"| '''Product''' || chromosome condensation and segregation SMC protein
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| |style="background:#ABCDEF;" align="center"|'''Function''' || segregation of replication origins
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU15940 smc]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=Smc Smc]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=Smc Smc]'''
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 135 kDa, 5.266
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 3558 bp, 1186 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[rnc]]'', ''[[ftsY]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU15940 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU15940 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU15940 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:smc_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=smc_1666560_1670120_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:smc_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU15940]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[DNA condensation/ segregation]]}},
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| {{SubtiWiki category|[[essential genes]]}}
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| = This gene is a member of the following [[regulons]] =
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU15940
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| ===Phenotypes of a mutant ===
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| * essential [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
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| * ''[[smc]]'' mutants are not viable on complex medim that allow rapid growth, but they are viable under conditions of slow growth {{PubMed|24440399,24440393}}
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU15940&redirect=T BSU15940]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/rnc-smc-ftsY.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11538]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:''' SMC family (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''[[Domains]]:'''
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| * '''Modification:'''
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| * '''[[Cofactors]]:'''
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| * '''Effectors of protein activity:'''
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| ** ATP-induced DNA-binding results in a more open conformation of the [[Smc]] dimer, and thus of the [[condension]] complex {{PubMed|25557547}}
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| * '''[[SubtInteract|Interactions]]:'''
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| ** part of the [[condensin]] complex {{PubMed|24440399,24440393}}
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| ** forms dimers {{PubMed|22385855}}
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| ** [[ScpA]]-[[Smc]] {{PubMed|12100548}}
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| ** [[ScpB]]-[[Smc]], {{PubMed|22385855,12100548,12421306}}, this interaction takes place only in the presence of [[ScpA]] {{PubMed|22385855}}
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| ** [[Smc]] is a member of a suspected group of hubs proteins that were suggested to be involved in a large number of [[SubtInteract|interactions]] {{PubMed|21630458}}
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| * '''[[Localization]]:'''
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| ** nucleoid (heterogeneous) {{PubMed|16479537}}
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| ** the [[condensin]] ([[Smc]])2-[[ScpA]]-[[ScpB]] complex forms two bipolar assemblies on the chromosome, one in each cell half, localization depends on [[Spo0J]] {{PubMed|24440393,23475963}}
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU15940&redirect=T BSU15940]
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| * '''Structure:'''
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| ** [http://www.pdb.org/pdb/explore/explore.do?structureId=3ZGX 3ZGX] (complex between the head domain of [[Smc]] (aa 1 - 219 and 983 - 1186) and the N-terminal winged-helix domain of [[ScpA]]) {{PubMed|23353789}}
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P51834 P51834]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU15940]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[rnc]]-[[smc]]-[[ftsY]]'' {{PubMed|11021934}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=smc_1666560_1670120_1 smc] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|11021934}}
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| * '''Regulation:'''
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| * '''Regulatory mechanism:'''
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| ** 1A822 ( ''smc''::''erm''), {{PubMed|12682299}}, available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A822&Search=1A822 BGSC]
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| ==Reviews==
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| <pubmed>19308706 22934648 22047950 22933559 24118085 </pubmed>
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| ==Original publications==
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| <pubmed>9791128,12100548,17416649,19450516,12421306,11395470, 19450517, 19450516 15009890 16479537 21630458 23353789 25071173 22385855 25951515 26253537 24440399,24440393 23475963 25557547 25664627</pubmed>
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| [[Category:Protein-coding genes]]
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