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| * '''Description:''' late competence protein, traffic ATPase, binds and transports transforming DNA <br/><br/>
| | {{#bank: ComGA}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''comGA''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || traffic ATPase
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| |style="background:#ABCDEF;" align="center"|'''Function''' || [[genetic competence]]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU24730 comGA]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=ComGA ComGA]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=ComGA ComGA]'''
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 40 kDa, 8.893
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1068 bp, 356 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[comGB]]'', ''[[corA]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU24730 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU24730 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU24730 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:comGA_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=comGA_2559007_2560077_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:comGA_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU24730]]
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[genetic competence]]}},
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| {{SubtiWiki category|[[membrane proteins]]}},
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| {{SubtiWiki category|[[phosphoproteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[ComK regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU24730
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU24730&redirect=T BSU24730]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/comGABCDEFG-yqzE.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10483]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' binds and transports transforming DNA
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| * '''Protein family:''' GSP E family (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| ** phosphorylated on Arg-28, Arg-71- and Arg-330 {{PubMed|22517742}}
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[ComGA]]-[[ComGB]] {{PubMed|15083159}}
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| ** [[ComGA]]-[[ComFA]] {{PubMed|17630974}}
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| ** [[ComEC]]-[[ComGA]] {{PubMed|17630974}}
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| ** [[Maf]]-[[ComGA]] {{PubMed|21564336}}
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| * '''[[Localization]]:'''
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| ** peripheral membrane protein [http://www.ncbi.nlm.nih.gov/pubmed/9723928 PubMed]
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| ** localizes to cell poles in competent cells [http://www.ncbi.nlm.nih.gov/pubmed/16009133 PubMed]
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| ** localizes to one cell pole {{PubMed|21278288}}
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU24730&redirect=T BSU24730]
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P25953 P25953]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU24730]
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| * '''E.C. number:'''
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| === Additional information===
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| * ComGA stability depends on [[Maf]] {{PubMed|21564336}}
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| =Expression and regulation=
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| * '''Operon:''' ''[[comGA]]-[[comGB]]-[[comGC]]-[[comGD]]-[[comGE]]-[[comGF]]-[[comGG]]-[[yqzE]]'' {{PubMed|2507524}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=comGA_2559007_2560077_-1 comGA] {{PubMed|22383849}}
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| * '''Sigma factor:''' [[SigA]] {{PubMed|2507524}}
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| * '''Regulation:'''
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| ** repressed by casamino acids [http://www.ncbi.nlm.nih.gov/pubmed/12107147 PubMed]
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| * '''Regulatory mechanism:'''
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| ** [[ComK]]: transcription activation {{PubMed|8196543}}
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| **GP1640 ''trpC2'' ''[[ymdB]]''::''spc'' P''comG-gfp'' (''cat''), available in [[ Jörg Stülke]]'s lab
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| **GP1643 P''comG-gfp'' (''cat'') in the NCIB3610 background, available in [[ Jörg Stülke]]'s lab
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| ==Reviews==
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| <pubmed> 15083159 </pubmed>
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| ==Original publications==
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| <pubmed>11814663,9422590,16009133,11298275,17630974,9723928,21278288,12107147, 8196543 2507524 21564336 21707789 22517742</pubmed>
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| [[Category:Protein-coding genes]]
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