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| * '''Description:''' transcriptional activator ([[transcription factors of the AraC family|AraC family]]), (AraC family DNA-binding domain fused to [[FeuA]]-like substrate-binding domain), regulation of the ''[[feuA]]-[[feuB]]-[[feuC]]-[[ybbA]]'' operon <br/><br/>
| | {{#bank: Btr}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''btr''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ybbB, yzbC''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || transcription activator ([[AraC]] family)
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of iron acquisition
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU01640 btr]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=btr btr]'''
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 60 kDa, 6.433
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1587 bp, 529 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[feuA]]'', ''[[ybbC]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU01640 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU01640 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU01640 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:ybbB_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ybbB_183414_185003_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:btr_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU01640]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[acquisition of iron]]}},
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| {{SubtiWiki category|[[iron metabolism]]}},
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| {{SubtiWiki category|[[transcription factors and their control]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[Fur regulon]]}}
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| =The [[Btr regulon]]:=
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| * ''[[feuA]]-[[feuB]]-[[feuC]]-[[ybbA]]''
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU01640
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU01640&redirect=T BSU01640]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/ybbB.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10834]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| ** binding of a direct repeat in the ''[[feuA]]'' promoter region and transcription activation of the ''[[feuA]]-[[feuB]]-[[feuC]]-[[ybbA]]'' operon in the presence of bacillibactin or enterobactin {{PubMed|17725565,22210890}}
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| * '''Protein family:'''[[transcription factors of the AraC family|AraC family]]
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):''' enterobactin, bacillibactin (co-activators) {{PubMed|17725565}}
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| * '''Effectors of protein activity:''' enterobactin, bacillibactin (co-activators) {{PubMed|17725565}}
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[Btr]]-[[RNA polymerase]] (perhaps [[SigA]]) {{PubMed|22210890}}
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| * '''[[Localization]]:'''
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU01640&redirect=T BSU01640]
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P40408 P40408]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU01640]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''btr'' {{PubMed|12354229}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ybbB_183414_185003_-1 btr] {{PubMed|22383849}}
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| * '''Sigma factor:'''
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| * '''Regulation:'''
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| ** expressed under conditions of iron starvation ([[Fur]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]
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| * '''Regulatory mechanism:'''
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| ** [[Fur]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed]
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| * '''Additional information:'''
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| ** the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>12884008,17725565, 22210890,12354229, 23199363 23504016 </pubmed>
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| [[Category:Protein-coding genes]]
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