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| * '''Description:''' Holliday junction DNA helicase, part of the [[RuvA]]-[[RuvB]] branch migration translocase <br/><br/>
| | {{#bank: RuvB}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''ruvB''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || Holliday junction DNA helicase
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || [[DNA repair/ recombination]]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU27730 ruvB]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=RuvB RuvB]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 37 kDa, 5.152
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1002 bp, 334 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yrzS]]'', ''[[ruvA]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU27730 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU27730 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU27730 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:ruvB_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ruvB_2835150_2836154_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:ruvB_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU27730]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[DNA repair/ recombination]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[LexA regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU27730
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU27730&redirect=T BSU27730]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/ruvAB.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG12669]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| ** [[RuvB]]-ATP stimulates [[RecU]]-mediated Holliday junction resolution {{PubMed|24770420}}
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| * '''Protein family:''' ruvB family (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''[[Domains]]:'''
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| * '''Modification:'''
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| * '''[[Cofactors]]:'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[RecU]]-[[RuvB]] {{PubMed|24770420,21600217}}
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| ** formation of a ternary complex [[RecU]]-[[RuvB]]-Holliday junction DNA {{PubMed|24770420}}
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| ** [[RuvA]]-[[RuvB]]
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| * '''[[Localization]]:''' cytoplasm (according to Swiss-Prot)
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU27730&redirect=T BSU27730]
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/O32055 O32055]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU27730]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[ruvA]]-[[ruvB]]'' {{PubMed|16267290}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ruvB_2835150_2836154_-1 ruvB] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:'''
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| * '''Regulation:'''
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| ** induced upon DNA damage ([[LexA]]) {{PubMed|16267290}}
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| * '''Regulatory mechanism:'''
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| ** [[LexA]]: transcription repression {{PubMed|16267290}}
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| ** 1A896 (no resistance), {{PubMed|16020779}}, available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A896&Search=1A896 BGSC]
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| == Reviews ==
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| <pubmed> 22933559 9442895</pubmed>
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| == Original publications ==
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| <pubmed>16267290, 24770420</pubmed>
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| [[Category:Protein-coding genes]]
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