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| * '''Description:''' phosphotransferase, attaches teichoic acid, teichuronic acid, or acidic capsular polysaccharide to cell wall peptidoglycan via phosphodiester linkage to N-acteylmuramic acid <br/><br/>
| | {{#bank: TagU}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''tagU''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' lytR''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || phosphotransferase, responsible for attachment of anionic polymers to peptidoglycan
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || transfer of anionic cell wall polymers from lipid-linked precursors to peptidoglycan
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU35650 tagU]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=TagU TagU]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 34 kDa, 9.527
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 918 bp, 306 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[lytA]]'', ''[[mnaA]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU35650 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU35650 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU35650 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:lytR_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=lytR_3663281_3664201_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:tagU_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU35650]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[cell wall synthesis]]}},
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| {{SubtiWiki category|[[cell envelope stress proteins (controlled by SigM, V, W, X, Y)]]}},
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| {{SubtiWiki category|[[membrane proteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[SigM regulon]]}},
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| {{SubtiWiki regulon|[[SigX regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU35650
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| ===Phenotypes of a mutant ===
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| * a ''[[tagU]]'' mutant has no phenoype, the triple ''[[tagT]] [[tagU]] [[tagV]]'' mutant is unable to grow under normal conditions {{PubMed|21964069}}
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU35650&redirect=T BSU35650]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/lytR.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10404]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:''' LytR-Cps2a-Psr family {{PubMed|19099556}}
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| * '''Paralogous protein(s):''' [[TagT]], [[TagV]]
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):''' Mg(2+) {{PubMed|21964069}}
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[MreB]]-[[TagU]] {{PubMed|21964069}}
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| * '''[[Localization]]:'''
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| ** cytoplasmic membrane (with extracytoplasmic catalaytic domain) {{PubMed|21964069}}
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU35650&redirect=T BSU35650]
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| * '''Structure:''' [http://www.pdb.org/pdb/explore/explore.do?structureId=3MEJ 3MEJ] ([[TagT]], 36% identity, 69% similarity)
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/Q02115 Q02115]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU35650]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''tagU'' {{PubMed|1357079}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=lytR_3663281_3664201_1 tagU] {{PubMed|22383849}}
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| * '''Sigma factor:''' [[SigA]] {{PubMed|1357079,9636707}}, [[SigM]] {{PubMed|19047346}}, [[SigX]] {{PubMed|1357079,9636707}}
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| * '''Regulation:'''
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| * '''Regulatory mechanism:'''
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| ** [[LytR]]: autorepression {{PubMed|1357079}}
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| * '''Additional information:'''
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| ** number of protein molecules per cell (minimal medium with glucose and ammonium): 188 {{PubMed|24696501}}
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>9636707,1357079 , 19099556 21964069 </pubmed>
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| [[Category:Protein-coding genes]]
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