WalR: Difference between revisions
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* '''Description:''' [[two-component systems|two-component]] response regulator, controls cell wall metabolism <br/><br/> | * '''Description:''' [[two-component systems|two-component]] response regulator ([[transcription factors of the OmpR family|OmpR family]]), controls cell wall metabolism <br/><br/> | ||
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|style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed] | |style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed] | ||
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|style="background:#ABCDEF;" align="center"| '''Product''' || [[two-component systems|two-component]] response regulator | |style="background:#ABCDEF;" align="center"| '''Product''' || [[two-component systems|two-component]] response regulator ([[transcription factors of the OmpR family|OmpR family]]) | ||
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|style="background:#ABCDEF;" align="center"|'''Function''' || control of cell wall metabolism | |style="background:#ABCDEF;" align="center"|'''Function''' || control of cell wall metabolism | ||
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* '''Catalyzed reaction/ biological activity:''' | * '''Catalyzed reaction/ biological activity:''' | ||
* '''Protein family:''' OmpR family of two-component | * '''Protein family:''' [[transcription factors of the OmpR family|OmpR family]] of two-component response regulators | ||
* '''Paralogous protein(s):''' | * '''Paralogous protein(s):''' | ||
Revision as of 11:09, 13 June 2014
- Description: two-component response regulator (OmpR family), controls cell wall metabolism
| Gene name | walR |
| Synonyms | yycF |
| Essential | yes PubMed |
| Product | two-component response regulator (OmpR family) |
| Function | control of cell wall metabolism |
| Gene expression levels in SubtiExpress: walR | |
| Interactions involving this protein in SubtInteract: WalR | |
| MW, pI | 27 kDa, 4.876 |
| Gene length, protein length | 705 bp, 235 aa |
| Immediate neighbours | walK, trnY-Phe |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Categories containing this gene/protein
cell wall/ other, transcription factors and their control, essential genes, phosphoproteins
This gene is a member of the following regulons
The WalR regulon
The gene
Basic information
- Locus tag: BSU40410
Phenotypes of a mutant
- essential PubMed
- a constitutively active form of WalR (WalR-R204C) results in constitutive expression of the WalR regulon, and in combination with a sepF mutation to the formation of cell wall-less L-forms PubMed
Database entries
- BsubCyc: BSU40410
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: OmpR family of two-component response regulators
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification: phosphorylated by WalK on an Asp residue
- Effectors of protein activity: phosphorylation likely affects DNA-binding activity
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- BsubCyc: BSU40410
- UniProt: P37478
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
- number of protein molecules per cell (minimal medium with glucose and ammonium): 176 PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
- Kevin Devine, Dublin
Your additional remarks
References
Reviews
<pubmed>19019149, 18245295,18792692, 22126136, 10094672 </pubmed>
The WalR regulon
<pubmed>17581128,10878122,12950927, 23199363</pubmed>
Other original Publications
<pubmed>18573169,17350627,10094672,17827301,9829949,16030236,19574649, 20059685 20111065 20167622 20834167 24125693 22122227 24125693 24490131 </pubmed>