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| * '''Description:''' para-aminobenzoate synthase (subunit B)/ anthranilate synthase (subunit II) <br/><br/>
| | {{#bank: PabA}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''pabA''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''trpG, trpX ''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || para-aminobenzoate synthase (subunit B)/ <br/>anthranilate synthase (subunit II) <br/>glutamine amidotransferase (subunit B) <br/>and anthranilate synthase (subunit II)
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| |style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of folate and tryptophan
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU00750 pabA]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=PabA PabA]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=pabA pabA]'''
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 21 kDa, 4.782
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 582 bp, 194 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[pabB]]'', ''[[pabC]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU00750 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU00750 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU00750 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:pabA_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=pabA_84290_84874_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:pabA_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU00750]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/><br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[biosynthesis/ acquisition of amino acids]]}},
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| {{SubtiWiki category|[[biosynthesis of cofactors]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[TRAP regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU00750
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU00750&redirect=T BSU00750]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/pabBAC-sul-folBK-yazB-yacF-lysS.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10138]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate (according to Swiss-Prot)
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| * '''Protein family:'''
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:''' [[PabA]]-[[PabB]], [[PabA]]-[[TrpE]]
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| * '''[[Localization]]:'''
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU00750&redirect=T BSU00750]
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P28819 P28819]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU00750]
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| * '''E.C. number:''' [http://www.expasy.org/enzyme/2.6.1.85 2.6.1.85]
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[pabB]]-[[pabA]]-[[pabC]]-[[sul]]-[[folB]]-[[folK]]-[[yazB]]-[[yacF]]-[[lysS]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/9084182 PubMed]
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=pabA_84290_84874_1 pabA] {{PubMed|22383849}}
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| * '''Sigma factor:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/9084182 PubMed]
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| * '''Regulation:''' translation repressed by tryptophan ([[MtrB]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/9084182 PubMed]
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| * '''Regulatory mechanism:''' [[MtrB]]: translation termination [http://www.ncbi.nlm.nih.gov/sites/entrez/9084182 PubMed]
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| * '''Additional information:'''
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| ** the ''[[pabA]]-[[pabC]]'' part of the mRNA is substantially stabilized upon depletion of [[Rny|RNase Y]] {{PubMed|21815947}}
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| ** number of protein molecules per cell (minimal medium with glucose and ammonium): 624 {{PubMed|24696501}}
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| ** number of protein molecules per cell (complex medium with amino acids, without glucose): 754 {{PubMed|24696501}}
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| ==Reviews==
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| <pubmed>16285852, 19385727</pubmed>
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| ==Original Publications==
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| <pubmed>8647825,7515880,9084182,17114263 ,21815947 , </pubmed>
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| [[Category:Protein-coding genes]]
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