TagB

• Description: putative CDP-glycerol:glycerol phosphate glycerophosphotransferase
  
  

Gene name	tagB
Synonyms
Essential	yes PubMed
Product	putative CDP-glycerol:glycerol phosphate glycerophosphotransferase
Function	biosynthesis of teichoic acid
Gene expression levels in SubtiExpress: tagB
Metabolic function and regulation of this protein in SubtiPathways: TagB
MW, pI	44 kDa, 8.925
Gene length, protein length	1143 bp, 381 aa
Immediate neighbours	tagA, tagC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, essential genes, membrane proteins

This gene is a member of the following regulons

PhoP regulon, WalR regulon

The gene

Basic information

• Locus tag: BSU35760

Phenotypes of a mutant

essential PubMed

Database entries

• BsubCyc: BSU35760

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: adds a single glycerol phosphate residue to the non-reducing end of the undecaprenol-phosphate-linked N-acetylmannosamine-β(1,4)-N-acetylglucosamine-1-phosphate PubMed

• Protein family: CDP-glycerol glycerophosphotransferase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane PubMed

Database entries

• BsubCyc: BSU35760

• Structure:

• UniProt: P27621

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: tagA-tagB PubMed

• Expression browser: tagB PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed when phosphate is available (PhoP) PubMed

• Regulatory mechanism:
  • PhoP: transcription repression PubMed
  • WalR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

<pubmed>18156271,9457886,17660278,7581998,16150696,7952180, 12950927 15547257 </pubmed>