PsdR: Difference between revisions
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* '''Description:''' [[two-component systems|two-component]] response regulator, induction of ''[[psdA]]-[[psdB]]'' in response to lipid II-binding lantibiotics, such as nisin and gallidermin <br/><br/> | * '''Description:''' [[two-component systems|two-component]] response regulator ([[transcription factors of the OmpR family|OmpR family]]), induction of ''[[psdA]]-[[psdB]]'' in response to lipid II-binding lantibiotics, such as nisin and gallidermin <br/><br/> | ||
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
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|style="background:#ABCDEF;" align="center"| '''Product''' || [[two-component systems|two-component]] response regulator | |style="background:#ABCDEF;" align="center"| '''Product''' || [[two-component systems|two-component]] response regulator ([[transcription factors of the OmpR family|OmpR family]]) | ||
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|style="background:#ABCDEF;" align="center"|'''Function''' || resistance against toxic peptides | |style="background:#ABCDEF;" align="center"|'''Function''' || resistance against toxic peptides | ||
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=== Additional information=== | === Additional information=== | ||
=The protein= | =The protein= | ||
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* '''Catalyzed reaction/ biological activity:''' | * '''Catalyzed reaction/ biological activity:''' | ||
* '''Protein family:''' OmpR family of two-component response regulators | * '''Protein family:''' [[transcription factors of the OmpR family|OmpR family]] of two-component response regulators | ||
* '''Paralogous protein(s):''' | * '''Paralogous protein(s):''' | ||
Revision as of 11:11, 13 June 2014
- Description: two-component response regulator (OmpR family), induction of psdA-psdB in response to lipid II-binding lantibiotics, such as nisin and gallidermin
| Gene name | psdR |
| Synonyms | yvcP |
| Essential | no |
| Product | two-component response regulator (OmpR family) |
| Function | resistance against toxic peptides |
| Gene expression levels in SubtiExpress: psdR | |
| Interactions involving this protein in SubtInteract: PsdR | |
| MW, pI | 27 kDa, 4.676 |
| Gene length, protein length | 711 bp, 237 aa |
| Immediate neighbours | psdS, yvzJ |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Categories containing this gene/protein
transcription factors and their control, resistance against toxins/ antibiotics, phosphoproteins
This gene is a member of the following regulons
The PsdR regulon: psdA-psdB
The gene
Basic information
- Locus tag: BSU34720
Phenotypes of a mutant
Database entries
- BsubCyc: BSU34720
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: OmpR family of two-component response regulators
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: phosphorylated by PsdS on an Asp residue
- Cofactor(s):
- Effectors of protein activity: phosphorylation likely affects DNA-binding activity
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- BsubCyc: BSU34720
- Structure:
- UniProt: O06978
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed <pubmed>10094672,18394148,14651641 21283517</pubmed>