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| * '''Description:''' excinuclease ABC (subunit C) <br/><br/>
| | {{#bank: UvrC}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''uvrC''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''uvrB ''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || excinuclease ABC (subunit C)
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || DNA repair after UV damage
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU28490 uvrC]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=UvrC UvrC]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 69 kDa, 9.503
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1794 bp, 598 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[lysC]]'', ''[[trxA]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU28490 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU28490 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU28490 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:uvrC_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=uvrC_2911116_2912888_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:uvrC_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU28490]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[DNA repair/ recombination]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[LexA regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU28490
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU28490&redirect=T BSU28490]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/uvrC.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10349]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:''' uvrC family (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[UvrB]]-[[UvrC]] {{PubMed|16464004}}
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| * '''[[Localization]]:'''
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU28490&redirect=T BSU28490]
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| * '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=3C65 3C65] (5' endonuclease domain, Geobacillus stearothermophilus)
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P14951 P14951]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU28490]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''uvrC'' {{PubMed|16267290}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=uvrC_2911116_2912888_-1 uvrC] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:'''
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| * '''Regulation:'''
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| ** induced upon DNA damage ([[LexA]]) {{PubMed|16267290}}
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| * '''Regulatory mechanism:'''
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| ** [[LexA]]: transcription repression {{PubMed|16267290}}]
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| ==Reviews==
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| <pubmed>16464004 15927210 7801120 22933559 </pubmed>
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| == Original publications ==
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| <pubmed>2174442,2559145 ,16267290, </pubmed>
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| [[Category:Protein-coding genes]]
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