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| * '''Description:''' spore coat protein (outer) <br/><br/>
| | {{#bank: CotC}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''cotC''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Product''' || spore coat protein (outer)
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || resistance of the spore
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| |-
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU17700 cotC]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=CotC CotC]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 14 kDa, 9.558
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 354 bp, 118 aa
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ynzK]]'', ''[[tatAC]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU17700 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU17700 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU17700 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:cotC_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |-
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=cotC_1904995_1905195_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:cotC_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU17700]]
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[sporulation proteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[GerE regulon]]}},
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| {{SubtiWiki regulon|[[SigK regulon]]}},
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| {{SubtiWiki regulon|[[SpoIIID regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU17700
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU17700&redirect=T BSU17700]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/cotC.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10492]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:'''
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[CotC]]-[[CotU]] {{PubMed|18065538}}
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| ** [[CotE]]-[[CotC]] {{PubMed|20023017}}
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| * '''[[Localization]]:'''
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| ** outer spore coat, more abundant at the mother cell-distal pole of the forespore {{PubMed|19933362}}
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| ** the [[CotC]]-[[CotU]] complex assembles around the forming spore {{PubMed|18065538}}
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU17700&redirect=T BSU17700]
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P07790 P07790]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU17700]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''cotC'' (according to [http://dbtbs.hgc.jp/COG/prom/cotC.html DBTBS])
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=cotC_1904995_1905195_-1 cotC] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:''' [[SigK]] {{PubMed|1518043}}
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| * '''Regulation:'''
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| ** expressed late during sporulation in the mother cell ([[SigK]], [[GerE]], [[SpoIIID]]) {{PubMed|1518043,10788508}}
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| * '''Regulatory mechanism:'''
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| ** [[GerE]]: transcription activation {{PubMed|1518043}}
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| ** [[SpoIIID]]: transcription repression {{PubMed|10788508}}
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| ** 1S103 ( ''cotC''::''cat''), {{PubMed|2821284}}, available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S103&Search=1S103 BGSC]
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed> 19933362,1518043,2821284,12031481,1691789,18065538 10788508 20023017 15470121 </pubmed>
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| ==Application of CotZ for protein surface display==
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| '''Additional publications:''' {{PubMed|23334774}}
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| <pubmed> 17373477</pubmed>
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| [[Category:Protein-coding genes]]
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