FtsA

• Description: cell division protein, membrane anchor for FtsZ
  
  

Gene name	ftsA
Synonyms	spoIIN
Essential	no
Product	cell division protein
Function	formation of Z-ring
Gene expression levels in SubtiExpress: ftsA
Interactions involving this protein in SubtInteract: FtsA
MW, pI	47 kDa, 5.094
Gene length, protein length	1320 bp, 440 aa
Immediate neighbours	sbp, ftsZ
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell division, membrane proteins

This gene is a member of the following regulons

SigH regulon, WalR regulon

The gene

Basic information

• Locus tag: BSU15280

Phenotypes of a mutant

• cells become elongated PubMed
• the ftsA mutation is synthetically lethal with a sepF mutation PubMed

Database entries

• BsubCyc: BSU15280

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ftsA/mreB family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:
  • FtsZ-FtsA PubMed
  • PlsX-FtsA PubMed

• Localization:
  • septal at the cell membrane PubMed
  • septal localization depends on the proton motive force PubMed

Database entries

• BsubCyc: BSU15280

• Structure:

• UniProt: P28264

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ftsA-ftsZ PubMed

• Expression browser: ftsA PubMed

• Sigma factor: SigA PubMed, SigH PubMed

• Regulation:
  • activated by WalR PubMed

• Regulatory mechanism:

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 205 PubMed
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 422 PubMed

Biological materials

• Mutant:
  • 1A787 ( ftsA::cat), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

<pubmed> 19680248 </pubmed>

Original Publications

<pubmed>16796675,12081956,16159787,11298280,18776011,9287012,1569582,10878122,7592498, 20566861 23036588 23701187 24218584 24224907 24316672 </pubmed>