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| * '''Description:''' heme A synthase <br/><br/>
| | {{#bank: CtaA}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''ctaA''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || heme A synthase
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| |style="background:#ABCDEF;" align="center"|'''Function''' || heme biosynthesis
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU14870 ctaA]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 33 kDa, 9.644
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 918 bp, 306 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[pycA]]'', ''[[ctaB]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU14870 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU14870 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU14870 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:ctaA_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ctaA_1558034_1558954_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:ctaA_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU14870]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[biosynthesis of cofactors]]}},
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| {{SubtiWiki category|[[sporulation proteins]]}},
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| {{SubtiWiki category|[[membrane proteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[ResD regulon]]}},
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| {{SubtiWiki regulon|[[SigE regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU14870
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU14870&redirect=T BSU14870]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/ctaA.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10213]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' heme A synthesis from protoheme IX (heme B)
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| * '''Protein family:''' COX15/ctaA family, Type 1 subfamily (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| ** contains 8 transmembrane segments
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| * '''Modification:'''
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| * '''Cofactor(s):''' heme B
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:'''
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| ** cell membrane (according to Swiss-Prot)
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU14870&redirect=T BSU14870]
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P12946 P12946]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU14870]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''ctaA'' {{PubMed|2549007}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ctaA_1558034_1558954_-1 ctaA] {{PubMed|22383849}}
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| * '''Sigma factor:''' [[SigA]] {{PubMed|11325953}}, [[SigE]] {{PubMed|2549007,11325953}}
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| * '''Regulation:'''
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| ** expressed under anaerobic conditions ([[ResD]]) {{PubMed|10972837,11325953}}
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| * '''Regulatory mechanism:'''
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| ** [[ResD]]: transcription activation {{PubMed|10972837,11325953}}
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| == Reviews ==
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| <pubmed> 22484221 </pubmed>
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| == Original publications ==
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| <pubmed>15576792,7961419,16321940,11325953,18358840,7968515,15491161,10972837,,8665949,10972837, 2549007 19174544 </pubmed>
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| [[Category:Protein-coding genes]]
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