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| * '''Description:''' membrane DNA receptor, plays an important role in the transfer of transforming DNA into the DNA channel and in controlling the rate of DNA uptake <br/><br/>
| | {{#bank: ComEA}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''comEA''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''comD ''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || membrane DNA receptor
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| |style="background:#ABCDEF;" align="center"|'''Function''' || [[genetic competence]]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU25590 comEA]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=ComEA ComEA]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=comEA comEA]'''
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 21 kDa, 4.824
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 615 bp, 205 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[comEB]]'', ''[[comER]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU25590 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU25590 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU25590 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:comEA_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=comEA_2640513_2641130_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:comEA_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU25590]]
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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|
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[genetic competence]]}},
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| {{SubtiWiki category|[[membrane proteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[ComK regulon]]}},
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| {{SubtiWiki regulon|[[ComN regulon]]}}
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|
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU25590
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| ===Phenotypes of a mutant ===
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| * strongly reduced transformation rate {{PubMed|22398145}}
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/comEABC.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10480]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:'''
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''[[Domains]]:'''
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| ** extracellular DNA-binding domain
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| * '''Modification:'''
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| * '''[[Cofactors]]:'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[ComEC]]-[[ComEA]] {{PubMed|17630974}}
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| * '''[[Localization]]:'''
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| ** cell membrane, no distinct position {{PubMed|21278288}}
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| ** integral membrane protein {{PubMed|24164455}}
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| === Database entries ===
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| * '''Structure:''' [http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2DUY 2DUY] (from ''Thermus thermophilus hb8'', 37% identity, 60% similarity)
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P39694 P39694]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU25590]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[comEA]]-[[comEB]]-[[comEC]]'' {{PubMed|7968523,19028902}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=comEA_2640513_2641130_-1 comEA] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|7968523}}
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| * '''Regulation:'''
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| * '''Regulatory mechanism:'''
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| ** post-translational control by [[ComN]] {{PubMed|19028902}}
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| ** ''[[yutB]]'' is required for transcription {{PubMed|19028902}}
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| ** [[ComK]]: transcription activation {{PubMed|8196543}}
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| ==Reviews==
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| <pubmed> 15083159 </pubmed>
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| ==Original publications==
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| <pubmed>9987128,11814663,7768800,16751195,7968523,17630974, 21278288,19028902, 21707789 22398145 24164455</pubmed>
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| [[Category:Protein-coding genes]]
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