PtpZ

• Description: phosphotyrosine protein phosphatase, antagonist to PtkA
  
  

Gene name	ptpZ
Synonyms	ywqE
Essential	no
Product	phosphotyrosine protein phosphatase, antagonist to PtkA
Function	protein tyrosine dephosphorylation
Gene expression levels in SubtiExpress: ptpZ
Interactions involving this protein in SubtInteract: PtpZ
MW, pI	28 kDa, 6.66
Gene length, protein length	762 bp, 254 aa
Immediate neighbours	ugd, ptkA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biofilm formation, protein modification

This gene is a member of the following regulons

AbrB regulon

The gene

Basic information

• Locus tag: BSU36240

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate (according to Swiss-Prot), dephosphorylation of Ugd, TuaD and PtkA PubMed

• Protein family: cpsB/capC family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 3QY7 PubMed

• UniProt: P96717

• KEGG entry: [2]

• E.C. number: 3.1.3.48

Expression and regulation

• Operon: tkmA-ptkA-ptpZ-ugd PubMed

• Expression browser: ptpZ PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:
  • DegU-P: transcription repression PubMed
  • AbrB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:
  • GP1609 (spc), available in Jörg Stülke's lab
  • GP1610 (ptkA-ptpZ, spc), available in Jörg Stülke's lab

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

<pubmed>15866923,12970183, 21605684 20815827 21605684 20817675</pubmed>