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* '''Description:''' [[ABC transporter]] (permease) for the export of lipid II-binding lantibiotics, such as nisin and gallidermin<br/><br/>
{{#bank: PsdB}}


{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''psdB''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yvcS ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || [[ABC transporter]] (permease)
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || export of toxic peptides
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU34690 psdB]
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=PsdB PsdB]
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 73 kDa, 9.804 
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1938 bp, 646 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yvcT]]'', ''[[psdA]]''
|-
|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU34690 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU34690 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU34690 DNA_with_flanks]
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:yvcS_context.gif]]
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yvcS_3563581_3565521_-1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:psdB_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU34690]]
|-
|}
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= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[ABC transporters]]}},
{{SubtiWiki category|[[resistance against toxins/ antibiotics]]}},
{{SubtiWiki category|[[membrane proteins]]}}
= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[PsdR regulon]]}}
=The gene=
=== Basic information ===
* '''Locus tag:''' BSU34690
===Phenotypes of a mutant ===
=== Database entries ===
* '''DBTBS entry:''' no entry
* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG12408]
=== Additional information===
=The protein=
=== Basic information/ Evolution ===
* '''Catalyzed reaction/ biological activity:'''
* '''Protein family:''' ABC-4 integral membrane protein family (according to Swiss-Prot)
* '''Paralogous protein(s):'''
=== Extended information on the protein ===
* '''Kinetic information:'''
* '''Domains:'''
* '''Modification:'''
* '''Cofactor(s):'''
* '''Effectors of protein activity:'''
* '''[[SubtInteract|Interactions]]:'''
** [[PsdA]]-[[PsdB]] {{PubMed|10092453}}
* '''[[Localization]]:''' cell membrane (according to Swiss-Prot)
=== Database entries ===
* '''Structure:'''
* '''UniProt:''' [http://www.uniprot.org/uniprot/O06981 O06981]
* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU34690]
* '''E.C. number:'''
=== Additional information===
=Expression and regulation=
* '''Operon:'''
** ''[[psdA]]-[[psdB]]'' {{PubMed|18394148}}
** ''[[psdR]]-[[psdS]]-[[psdA]]-[[psdB]]'' {{PubMed|21078927}}
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yvcS_3563581_3565521_-1 psdB] {{PubMed|22383849}}
* '''Sigma factor:'''
** ''[[psdA]]'': [[SigA]] {{PubMed|21078927}}
** ''[[psdR]]'': [[SigA]] {{PubMed|21078927}}
* '''Regulation:'''
** ''[[psdA]]'': induced by nisin, gallidermin ([[PsdR]]) {{PubMed|21078927}}
* '''Regulatory mechanism:'''
** [[PsdR]]: transcription activation {{PubMed|21078927}}
* '''Additional information:'''
=Biological materials =
* '''Mutant:'''
* '''Expression vector:'''
       
* '''lacZ fusion:'''
* '''GFP fusion:'''
* '''two-hybrid system:'''
* '''Antibody:'''
=Labs working on this gene/protein=
=Your additional remarks=
=References=
'''Additional publications:''' {{PubMed|21078927}}
<pubmed>18394148,10092453, 21283517</pubmed>
[[Category:Protein-coding genes]]

Latest revision as of 14:51, 2 April 2014