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| * '''Description:''' required for processing and compartmentalization of pro-[[SigE]] <br/><br/>
| | {{#bank: SpoIIR}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''spoIIR''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ipc-27d, csfX ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || morphological chekcpoint for [[SigE]] processing
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || control of [[SigE]] activation
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU36970 spoIIR]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=SpoIIR SpoIIR]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 25 kDa, 4.737
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 672 bp, 224 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ywlB]]'', ''[[ywlA]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU36970 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU36970 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU36970 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:spoIIR_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=spoIIR_3794676_3795350_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:spoIIR_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU36970]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[sigma factors and their control]]}},
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| {{SubtiWiki category|[[sporulation proteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[SigF regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU36970
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/spoIIR.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10937]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' interacts with and activates the pro-[[SigE]] protease [[SpoIIGA]] in the intermembrane space between the forespore and the mother cell {{PubMed|22111992}}
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| * '''Protein family:'''
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| ** likely acylated on Thr-27 {{PubMed|22111992}}
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[SpoIIR]]-[[SpoIIGA]] {{PubMed|22111992}}
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| * '''[[Localization]]:'''
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| ** localizes initially to the forespore septal membrane (in a [[SpoIIGA]]-dependent manner), is then exported to the intermembrane space between the forespore and the mother cell {{PubMed|22111992}}
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| === Database entries ===
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P39151 P39151]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU36970]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' spoIIR (according to [http://dbtbs.hgc.jp/COG/prom/spoIIR.html DBTBS])
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=spoIIR_3794676_3795350_-1 spoIIR] {{PubMed|22383849}}
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| * '''Sigma factor:''' [[SigF]] {{PubMed|16497325}}
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| * '''Regulation:'''
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| ** expressed early during sporulation in the forespore ([[SigF]]) {{PubMed|16497325,15699190}}
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| * '''Regulatory mechanism:'''
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| '''Additional publications:''' {{PubMed|20802044,22111992}}
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| <pubmed>16497325,7585939,15044948,11849534, 19578359 </pubmed>
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| [[Category:Protein-coding genes]]
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