RNA polymerase: Difference between revisions
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* [[GreA]]: resolves promoter proximal pausing of RNA polymerase {{PubMed|21515770}} | * [[GreA]]: resolves promoter proximal pausing of RNA polymerase {{PubMed|21515770}} | ||
* [[CshA]]: [[DEAD-box RNA helicases|DEAD-box RNA helicase]] {{PubMed|21710567}} | * [[CshA]]: [[DEAD-box RNA helicases|DEAD-box RNA helicase]] {{PubMed|21710567}} | ||
* [[PcrA]]: ATP-dependent DNA helicase {{PubMed|24147116,21710567}} | |||
===Temporary interaction partners=== | ===Temporary interaction partners=== | ||
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* '''Additional interaction partners of the RNA polymerase (no specific subunit specified)''' | * '''Additional interaction partners of the RNA polymerase (no specific subunit specified)''' | ||
** [[HelD | ** [[HelD]], [[TopA]], [[CssR]], [[RnhC]], [[YpsC]], [[Mfd]], [[YpiA]], [[YdjO]], [[ResD]] {{PubMed|21710567}} | ||
==Back to [[protein-protein interactions]]== | ==Back to [[protein-protein interactions]]== | ||
Revision as of 18:48, 17 November 2013
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The enzyme responsible for transcription
- As an important difference as compared to the E. coli enzyme, the B. subtilis RNA polymerase has a strong preference for G as first nucleotides in transcripts PubMed
Components of the RNA polymerase
Core subunits
Sigma factors
- In addition to the housekeeping sigma factor, SigA, there are several other sigma factors with different promoter recognition specifiity that are active under specific conditions (such as stress or sporulation)
Small accessory subunits
Other interaction partners
- NusA: essential elongation factor
- GreA: resolves promoter proximal pausing of RNA polymerase PubMed
- CshA: DEAD-box RNA helicase PubMed
- PcrA: ATP-dependent DNA helicase PubMed
Temporary interaction partners
- Spx: transcription regulator, interacts with RpoA
- MgsR: transcription regulator orthologous to Spx, interacts with RpoA
- Btr: transcription activator PubMed
- YlyA: modulates SigG-dependent transcription PubMed
- Additional interaction partners of the RNA polymerase (no specific subunit specified)
Back to protein-protein interactions
References
Reviews
<pubmed> 18599813 7708009 18410247 19889534 19489723 18280161 21233849 22210308 23433801 23768203 </pubmed>
The structure of RNA polymerase
<pubmed> 12732296 12581657 11297923 19735077 </pubmed>
Important original publications
<pubmed> 21350489 21515770 22333917,20817769,20724389,21710567 23761441 23875654 23771146 </pubmed>