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=== Additional information===
=== Additional information===


=The protein=
=The protein=
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* '''Kinetic information:'''
* '''Kinetic information:'''


* '''Domains:'''  
* '''[[Domains]]:'''  


* '''Modification:'''
* '''Modification:'''


* '''Cofactor(s):'''
* '''[[Cofactors]]:'''


* '''Effectors of protein activity:'''
* '''Effectors of protein activity:'''
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=pgsC_3698982_3699431_-1 capC] {{PubMed|22383849}}
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=pgsC_3698982_3699431_-1 capC] {{PubMed|22383849}}


* '''Sigma factor:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/19420703 PubMed]
* '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/19420703 PubMed]


* '''Regulation:'''  
* '''Regulation:'''  
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* '''Regulatory mechanism:''' activated by [[DegU]]-P [http://www.ncbi.nlm.nih.gov/sites/entrez/19420703 PubMed]
* '''Regulatory mechanism:''' activated by [[DegU]]-P [http://www.ncbi.nlm.nih.gov/sites/entrez/19420703 PubMed]


* '''Additional information:''' The operon is not expressed in the lab strain 168 due to lack of expression of [[DegQ]] resulting in inactivity of [[DegS]] and [[DegU]] {{PubMed|21965392}}
* '''Additional information:'''  
** The operon is not expressed in the lab strain 168 due to lack of expression of [[DegQ]] resulting in inactivity of [[DegS]] and [[DegU]] {{PubMed|21965392}}
** expression of the operon is reduced in ''[[motA]]'' or ''[[motB]]'' mutants due to reduced [[DegU]] phosphorylation {{PubMed|24296669}}


=Biological materials =
=Biological materials =
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<pubmed>20735481 </pubmed>
<pubmed>20735481 </pubmed>
==Original publications==
==Original publications==
'''Additional publications:''' {{PubMed|21965392}}
<pubmed>11751809,19420703, 16233197 20564357 20564574 24296669 21965392</pubmed>
<pubmed>11751809,19420703, 16233197 20564357 20564574 </pubmed>


[[Category:Protein-coding genes]]
[[Category:Protein-coding genes]]

Revision as of 20:13, 4 December 2013

  • Description: capsular polyglutamate biosynthesis

Gene name capC
Synonyms ywtA, pgsC
Essential no
Product unknown
Function capsule synthesis
Gene expression levels in SubtiExpress: capC
MW, pI 16 kDa, 9.672
Gene length, protein length 447 bp, 149 aa
Immediate neighbours capA, capB
Sequences Protein DNA DNA_with_flanks
Genetic context
This image was kindly provided by SubtiList
Expression at a glance   PubMed















Categories containing this gene/protein

capsule biosynthesis and degradation

This gene is a member of the following regulons

DegU regulon

The gene

Basic information

  • Locus tag: BSU35890

Phenotypes of a mutant

no synthesis of the poly-gamma-glutamate capsule PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Additional information:
    • The operon is not expressed in the lab strain 168 due to lack of expression of DegQ resulting in inactivity of DegS and DegU PubMed
    • expression of the operon is reduced in motA or motB mutants due to reduced DegU phosphorylation PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

<pubmed>20735481 </pubmed>

Original publications

<pubmed>11751809,19420703, 16233197 20564357 20564574 24296669 21965392</pubmed>