ComFC

• Description: late competence gene
  
  

Gene name	comFC
Synonyms
Essential	no
Product	unknown
Function	compentence
Gene expression levels in SubtiExpress: comFC
MW, pI	26 kDa, 8.851
Gene length, protein length	687 bp, 229 aa
Immediate neighbours	yvyF, comFB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

genetic competence, phosphoproteins

This gene is a member of the following regulons

ComK regulon

The gene

Basic information

• Locus tag: BSU35450

Database entries

• BsubCyc: BSU35450

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: comF/gntX family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:
  • phosphorylated on Arg-74 PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • localizes to one or both cell poles PubMed

Database entries

• BsubCyc: BSU35450

• Structure:

• UniProt: P39147

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: comFA-comFB-comFC-yvyF-flgM-yvyG-flgK-flgL PubMed

• Expression browser: comFC PubMed

• Sigma factor: comFA: SigA PubMed

• Regulation:

• Regulatory mechanism:
  • ComK: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector: for expression, purification in E. coli with N-terminal His-tag, pRSETA available in Gerth lab

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

<pubmed>11814663,8412657,21278288, 22517742</pubmed>