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| * '''Description:''' [[penicillin-binding protein]] 4A, D-alanyl-D-alanine carboxypeptidase <br/><br/>
| | {{#bank: DacC}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''dacC''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''pbp ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || [[penicillin-binding protein]] 4A, <br/>D-alanyl-D-alanine carboxypeptidase
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| |style="background:#ABCDEF;" align="center"|'''Function''' || carboxypeptidase
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU18350 dacC]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 52 kDa, 5.413
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1473 bp, 491 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ppsA]]'', ''[[galM]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU18350 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU18350 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU18350 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:dacC_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=dacC_1998340_1999815_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:dacC_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU18350]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[cell wall synthesis]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[SigH regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU18350
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yoxA-dacC.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10969]
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| === Additional information===
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| * A mutation was found in this gene after evolution under relexed selection for sporulation {{PubMed|21821766}}
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' cleavage ofD-Ala-D-Ala interpeptide bridges in peptidoglycan {{PubMed|19758330}}
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| * '''Protein family:'''
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** may be part of the [[cell wall biosynthetic complex]] {{PubMed|17981078}}
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| * '''[[Localization]]:'''
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| === Database entries ===
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| * '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=1W5D 1W5D], [http://www.rcsb.org/pdb/explore.do?structureId=2J9P 2J9P] (complex with a peptidoglycan mimetic peptide)
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P39844 P39844]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU18350]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[galM]]-[[dacC]]'' {{PubMed|9733705}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=dacC_1998340_1999815_-1 dacC] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:''' [[SigH]] {{PubMed|9733705}}, [[SigB]] {{PubMed|10482513}}
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| * '''Regulation:'''
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| * '''Regulatory mechanism:'''
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed> 9733705 10482513 19758330 14731276,17582436 ,9864321, 21821766 22029692 23560856 </pubmed>
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| [[Category:Protein-coding genes]]
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