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| * '''Description:''' endo-1,4-beta-glucanase <br/><br/>
| | {{#bank: BglC}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''bglC''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''eglS ''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || endo-1,4-beta-glucanase)
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| |style="background:#ABCDEF;" align="center"|'''Function''' || beta-1,4-glucan degradation
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU18130 bglC]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 55 kDa, 8.619
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1497 bp, 499 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[alsT]]'', ''[[ynfE]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU18130 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU18130 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU18130 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:bglC_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=eglS_1940625_1942124_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:bglC_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU18130]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[utilization of specific carbon sources]]}}
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| = This gene is a member of the following [[regulons]] =
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU18130
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/bglC.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10437]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans (according to Swiss-Prot)
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| * '''Protein family:''' glycosyl hydrolase 5 (cellulase A) family (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:''' extracellular (signal peptide) [http://www.ncbi.nlm.nih.gov/pubmed/18957862 PubMed]
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| === Database entries ===
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| * '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=3PZT 3PZT] {{PubMed|21880019}}
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P10475 P10475]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU18130]
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| * '''E.C. number:''' [http://www.expasy.org/enzyme/3.2.1.4 3.2.1.4]
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''bglC'' (according to [http://dbtbs.hgc.jp/COG/prom/bglC.html DBTBS])
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=eglS_1940625_1942124_1 bglC] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|3106328}}
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| * '''Regulation:'''
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| * '''Regulatory mechanism:'''
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| ** 1A751 (no resistance), {{PubMed|7704256}}, available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A751&Search=1A751 BGSC]
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| ** 1A752 (no resistance), {{PubMed|7704256}}, available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A752&Search=1A752 BGSC]
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| ** 1A976 (no resistance), {{PubMed|21255377}}, available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A976&Search=1A976 BGSC]
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>18957862,3024130 21880019 3106328 23543074 </pubmed>
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| [[Category:Protein-coding genes]]
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