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Revision as of 13:02, 16 May 2013

Gene name phrA
Synonyms gsiAB
Essential no
Product phosphatase (RapA) inhibitor
Function control of sporulation initiation
Gene expression levels in SubtiExpress: phrA
Interactions involving this protein in SubtInteract: PhrA
Function and regulation of this protein in SubtiPathways:
Phosphorelay
MW, pI 4 kDa, 10.229
Gene length, protein length 132 bp, 44 aa
Immediate neighbours rapA, yjpA
Sequences Protein DNA DNA_with_flanks
Genetic context
This image was kindly provided by SubtiList
Expression at a glance   PubMed




























Categories containing this gene/protein

phosphorelay, quorum sensing, short peptides

This gene is a member of the following regulons

CodY regulon, ComA regulon, Spo0A regulon

The gene

Basic information

  • Locus tag: BSU12440

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: phr family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed by glucose (4.2-fold) (CcpA) PubMed
    • repressed by casamino acids PubMed
    • repressed under conditions that trigger sporulation (Spo0A) PubMed
    • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
    • expressed at high cell density (ComA) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed <pubmed>8643670,8730857,11923303,1378051,14651647,12618455, 12107147, 19380751 16091051 20238180 </pubmed>