AcuC

• Description: protein deacetylase for the control of AcsA activity
  
  

Gene name	acuC
Synonyms
Essential	no
Product	AcsA deacetylase
Function	control of AcsA activity
Gene expression levels in SubtiExpress: acuC
MW, pI	42 kDa, 5.062
Gene length, protein length	1161 bp, 387 aa
Immediate neighbours	acuB, motS
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of specific carbon sources, utilization of lipids, protein modification

This gene is a member of the following regulons

CcpA regulon

The gene

Basic information

• Locus tag: BSU29710

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: deacetylates (and thereby activates) AcsA (together with SrtN) PubMed

• Protein family: histone deacetylase family (according to Swiss-Prot) class I histone deacetylase

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P39067

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: acuA-acuB-acuC PubMed

• Expression browser: acuC PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed by glucose (CcpA) PubMed

• Regulatory mechanism:
  • CcpA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:
  • GP1209 (acuC::kan), available in Stülke lab
  • GP1213 (srtN::cat)(acuC::kan), available in Stülke lab** 1A887 ( acuC::spc), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

<pubmed>7913927,,16855235,7934817, 19136592, 18487328 </pubmed>