SpoIIIAE

• Description: component of the SpoIIIA-SpoIIQ type III secretion system residing in the forespore membrane, required for SigG activation
  
  

Gene name	spoIIIAE
Synonyms
Essential	no
Product	component of a type III secretion system
Function	activation of SigG
Gene expression levels in SubtiExpress: spoIIIAE
Interactions involving this protein in SubtInteract: SpoIIIAE
MW, pI	43 kDa, 6.587
Gene length, protein length	1215 bp, 405 aa
Immediate neighbours	spoIIIAF, spoIIIAD
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed File:SpoIIIAE expression.png

Categories containing this gene/protein

protein secretion, sporulation proteins, membrane proteins

This gene is a member of the following regulons

SigE regulon, SpoIIID regulon

The gene

Basic information

• Locus tag: BSU24390

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • SpoIIIAE-SpoIIIJ (in membrane)PubMed

• Localization:
  • membrane protein PubMed, insertion into the membrane requires SpoIIIJ PubMed

Database entries

• Structure:

• UniProt: P49782

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: spoIIIAA-spoIIIAB-spoIIIAC-spoIIIAD-spoIIIAE-spoIIIAF-spoIIIAG-spoIIIAH PubMed

• Expression browser: spoIIIAE PubMed

• Sigma factor: SigE PubMed

• Regulation: expressed during sporulation in the mother cell (SigE) PubMed, switched off by SpoIIID PubMed

• Regulatory mechanism: SpoIIID: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Richard Losick, Harvard University, Cambridge, USA homepage

Adriano Henriques, Lisbon, Portugal homepage

References

<pubmed>1766372,18485064,18820020,19609349 , </pubmed>