Easter egg: Difference between revisions

Revision as of 13:21, 9 November 2010

Biofilms are the result of the multicellular lifestyle of B. subtilis. They are characterized by the formation of a matrix polysaccharide and an amyloid-like protein, TasA.

Gene name	sinR
Synonyms	sin, flaD
Essential	no
Product	transcriptional regulator of post-exponential-phase responses genes
Function	control of biofilm formation
Metabolic function and regulation of this protein in SubtiPathways: Biofilm, Central C-metabolism
MW, pI	12 kDa, 7.177
Gene length, protein length	333 bp, 111 aa
Immediate neighbours	sinI, tasA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Biofilm formation in SubtiPathways

Labs working on biofilm formation

Key genes and operons involved in biofilm formation

matrix polysaccharide synthesis:
- epsA-epsB-epsC-epsD-epsE-epsF-epsG-epsH-epsI-epsJ-epsK-epsL-epsM-epsN-epsO
amyloid protein synthesis
- yqxM-sipW-tasA
regulation
- SlrR
- SlrA
- SinR
- SinI
- PtkA
- TkmA
- PtpZ
- DegU
- RacX
biofilm disassembly
- YlmE
other proteins required for biofilm formation
- SpeA
- YmcA
- YxaB

Key reviews

additional reviews: PubMed

@@ Line 1: / Line 1: @@
-[[Image:funny.jpg]]
+Biofilms are the result of the multicellular lifestyle of ''B. subtilis''. They are characterized by the formation of a matrix polysaccharide and an amyloid-like protein, [[TasA]].
+{| align="right" border="1" cellpadding="2"
+|-
+|style="background:#ABCDEF;" align="center"|'''Gene name'''
+|''sinR''
+|-
+|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''sin, flaD ''
+|-
+|style="background:#ABCDEF;" align="center"| '''Essential''' || no
+|-
+|style="background:#ABCDEF;" align="center"| '''Product''' || transcriptional regulator of post-exponential-phase responses genes
+|-
+|style="background:#ABCDEF;" align="center"|'''Function''' || control of [[biofilm formation]]
+|-
+|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/biofilm.html Biofilm], [http://subtiwiki.uni-goettingen.de/pathways/carbon_flow.html Central C-metabolism]'''
+|-
+|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 12 kDa, 7.177
+|-
+|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 333 bp, 111 aa
+|-
+|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[sinI]]'', ''[[tasA]]''
+|-
+|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB14392&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
+|-
+|colspan="2" | '''Genetic context''' <br/> [[Image:sinR_context.gif]]
+ <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
+|-
+|}
+__TOC__
+==[http://subtiwiki.uni-goettingen.de/pathways/biofilm.html Biofilm formation in ''Subti''Pathways]==
+==Labs working on biofilm formation==
+* [[Daniel Kearns]]
+* [[Oscar Kuipers]]
+* [[Beth Lazazzera]]
+* [[Richard Losick]]
+* [[Nicola Stanley-Wall]]
+==Key genes and operons involved in biofilm  formation==
+* matrix polysaccharide synthesis:
+** ''[[epsA]]-[[epsB]]-[[epsC]]-[[epsD]]-[[epsE]]-[[epsF]]-[[epsG]]-[[epsH]]-[[epsI]]-[[epsJ]]-[[epsK]]-[[epsL]]-[[epsM]]-[[epsN]]-[[epsO]]''
+* amyloid protein synthesis
+** ''[[yqxM]]-[[sipW]]-[[tasA]]''
+* regulation
+** [[SlrR]]
+** [[SlrA]]
+** [[SinR]]
+** [[SinI]]
+** [[PtkA]]
+** [[TkmA]]
+** [[PtpZ]]
+** [[DegU]]
+** [[RacX]]
+* biofilm disassembly
+** [[YlmE]]
+* other proteins required for biofilm formation
+** [[SpeA]]
+** [[YmcA]]
+** [[YxaB]]
+==Key reviews==
+<pubmed>19054118 19054118 16787201 9891794 20890834  </pubmed>
+* additional reviews: {{PubMed|20735481}}