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Revision as of 14:27, 4 April 2012

Welcome to SubtiWiki! - Bacillus subtilis annotation the "wiki" way!

Contact: General Microbiology, University of Göttingen, send mail

Upcoming events:

April 16 - 19, 2012: The 5th European Spore Conference will take place in London, UK. contact, conference website
April 24 - 25, 2012: The BACELL meeting 2012 will be organized by Kevin Devine in Dublin, Ireland. contact, The deadline for registration is approaching!

Past conferences

New: Subtiwiki is now on Facebook - please give it a +1!

Now online: A description of SubtiWiki, SubtiPathways, and SubtInteract in the 2012 Database issue of Nucleic Acids Research <pubmed> 22096228 </pubmed>

Paper of the month: April 2012

Meisner et al. and Levdikov et al. from the labs of Charles Moran and Tony Wilkinson, respectively, have reported the structure of the complex between SpoIIQ and SpoIIIAH. These two proteins interact through two membranes to connect the forespore and the mother cell during sporulation. The structure of the complex suggests that it is the extracellular component of a gap junction-like intercellular channel for the traffic of proteins between the two compartments.
Relevant SubtiWiki pages: Charles Moran, Tony Wilkinson, sporulation, SpoIIQ, SpoIIIAH

Levdikov VM, Blagova EV, McFeat A, Fogg MJ, Wilson KS, Wilkinson AJ  
Structure of components of an intercellular channel complex in sporulating Bacillus subtilis. 
Proc Natl Acad Sci U S A. 2012 Mar 19. [Epub ahead of print] 
PubMed:22431604

Previous papers of the month

New procedure for account creation:

Due to massive spam attacks, we had to change our policy for the creation of accounts. If you want to create an account, just send me a mail. We will create the account for you as quickly as possible, then you can change your password. This does not affect existing accounts, which remain active.
Please remember that all members of the Bacillus community are invited to create accounts and to contribute to SubtiWiki!

News in SubtiWiki:

June 2011: updated Excel files that map all genes to categories and regulons as well as the general updated identity mapping of all genes were uploaded.
April 2011: SubtInteract, a presentation of protein-protein interactions in B. subtilis, is online!
December 2010: SubtiCellPublisher allows the conversion of CellDesigner diagrams to navigatable presentations in the style of SubtiPathways
December 2010: all genes are linked to regulons, and the pages of the regulons provide an overview on all genes that are members of this specific regulon.
December 2010: all genes/proteins are linked to categories, and the pages of the categories provide an overview on all genes/proteins that are members of this specific category.
August 2010: several new pathway maps including Utilization of other nitrogen sources, Biotin synthesis, Murein recycling, and Protein secretion were uploaded to SubtiPathways
March 2010: novel plasmids for the creation of strains expressing proteins with a C-terminal triple FLAG-tag (for simple immunological analysis of the proteins, pGP1087 and pGP1331)

Genes (examples)	Additional pages
spo0A	SubtiPathways
glnA	Lists of genes, proteins and RNAs
rny	Categories
psdA	Regulons
pckA	methods
dnaA	metabolism
rnpA	protein-protein interactions
sigB	genome-wide analyses
ptkA	list of plasmids
mreC	labs working on Bacillus
ccpA	*the people behind SubtiWiki*
sr1	template

Publications describing SubtiWiki and SubtiPathways:

@@ Line 20: / Line 20: @@
 <br/>
-<big>'''Paper of the month: March 2012'''</big>
+<big>'''Paper of the month: April 2012'''</big>
-* [http://www.ncbi.nlm.nih.gov/pubmed/22383848 Buescher ''et al''.] and [http://www.ncbi.nlm.nih.gov/pubmed/22383849 Nicolas ''et al''.] from the BaSysBio consortium directed by [[Philippe Noirot]] studied the dynamic metabolic and transcriptional responses of ''B. subtilis'' to changes of the growth conditions. One of the major issues is the adaptation of the cells upon a nutrient switch from glucose to malate and ''vice versa''. Importantly, the study by [http://www.ncbi.nlm.nih.gov/pubmed/22383849 Nicholas ''et al''.] provides an analysis of gene expression at 104 different conditions as revealed by tiling arrays.
+* [http://www.ncbi.nlm.nih.gov/pubmed/22431613 Meisner ''et al''.] and [http://www.ncbi.nlm.nih.gov/pubmed/22431604 Levdikov ''et al''.] from the labs of [[Charles Moran]] and [[Tony Wilkinson]], respectively, have reported the structure of the complex between [[SpoIIQ]] and [[SpoIIIAH]]. These two proteins interact through two membranes to connect the forespore and the mother cell during [[sporulation proteins|sporulation]]. The structure of the complex suggests that it is the extracellular component of a gap junction-like intercellular channel for the traffic of proteins between the two compartments.
-* '''Relevant ''Subti''Wiki pages:'''  [[Philippe Noirot]], [[Michael Hecker]], [[Uwe Völker]], [[Philippe Bessières]], [[Uwe Sauer]], [[Stephane Aymerich]], [[Tony Wilkinson]], [[metabolism]], [[transcription]], [[CcpA]], [[Sigma factors]], [[ncRNA|sRNAs]], [[Rho]]
+* '''Relevant ''Subti''Wiki pages:'''  [[Charles Moran]], [[Tony Wilkinson]], [[sporulation proteins|sporulation]], [[SpoIIQ]], [[SpoIIIAH]]
-<pubmed>22383848 22383849</pubmed>
+ <big>''Levdikov VM, Blagova EV, McFeat A, Fogg MJ, Wilson KS, Wilkinson AJ''  </big>
-* '''A comment on these papers:'''
+ <big>'''Structure of components of an intercellular channel complex in sporulating ''Bacillus subtilis''.''' </big>
-<pubmed> 22383834 </pubmed>
+ <big>Proc Natl Acad Sci U S A. 2012 Mar 19. [Epub ahead of print] </big>
+ [http://www.ncbi.nlm.nih.gov/pubmed/22431604 PubMed:22431604]
+<pubmed> 22431613</pubmed>
 * [[Previous papers of the month]]