DacC

• Description: penicillin-binding protein 4A, D-alanyl-D-alanine carboxypeptidase
  
  

Gene name	dacC
Synonyms	pbp
Essential	no
Product	penicillin-binding protein 4A, D-alanyl-D-alanine carboxypeptidase
Function	carboxypeptidase
MW, pI	52 kDa, 5.413
Gene length, protein length	1473 bp, 491 aa
Immediate neighbours	ppsA, galM
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

cell wall synthesis

This gene is a member of the following regulons

SigH regulon

The gene

Basic information

• Locus tag: BSU18350

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Additional information

• A mutation was found in this gene after evolution under relexed selection for sporulation PubMed

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: cleavage ofD-Ala-D-Ala interpeptide bridges in peptidoglycan PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • may be part of the cell wall biosynthetic complex PubMed

• Localization:

Database entries

• Structure: 1W5D, 2J9P (complex with a peptidoglycan mimetic peptide)

• UniProt: P39844

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: galM-dacC PubMed

• Expression browser: dacC PubMed

• Sigma factor: SigH PubMed, SigB PubMed

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

<pubmed> 9733705 10482513 19758330 14731276,17582436 ,9864321, 21821766 22029692 </pubmed>