RNA polymerase

Parent categories	3. Information processing 3.2. RNA synthesis and degradation 3.2.1. Transcription
Neighbouring categories	Sigma factors
Related categories	protein-protein interactions transcription
Overview on the categories (Excel file) All genes and their categories (Excel file)

Components of the RNA polymerase

Core subunits

• RpoA: alpha subunit
• RpoB: beta subunit
• RpoC: beta' subunit

• The stoichiometry of the enzyme is RpoA(2)-RpoB-RpoC

Sigma factors

• In addition to the housekeeping sigma factor, SigA, there are several other sigma factors with different promoter recognition specifiity that are active under specific conditions (such as stress or sporulation)

Small accessory subunits

• RpoE: delta subunit
• YloH: omega subunit

Other interaction partners

• NusA: essential elongation factor
• GreA: resolve promoter proximal pausing of RNA polymerase PubMed
• CshA

Temporary interaction partners

• Spx: transcription regulator, interacts with RpoA
• MgsR: transcription regulator orthologous to Spx, interacts with RpoA

• Additional interaction partners of the RNA polymerase (no specific subunit specified)
  • HelD, PcrA, TopA, YvqA, RnhC, CshA, YpsC, Mfd, YpiA, YdjO, ResD PubMed

References

Reviews

<pubmed> 18599813 7708009 18410247 19889534 19489723 18280161 21233849 </pubmed>

The structure of RNA polymerase

<pubmed> 12732296 12581657 11297923 19735077 </pubmed>

Important original publications: PubMed

<pubmed> 21350489 21515770 </pubmed> <pubmed> 21710567 </pubmed>