TagF

• Description: CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase
  
  

Gene name	tagF
Synonyms	rodC
Essential	yes PubMed
Product	CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase
Function	biosynthesis of teichoic acid
MW, pI	87 kDa, 9.4
Gene length, protein length	2238 bp, 746 aa
Immediate neighbours	tagG, tagE
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, essential genes, membrane proteins

This gene is a member of the following regulons

PhoP regulon, WalR regulon

The gene

Basic information

• Locus tag: BSU35720

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: CDP-glycerol + (glycerophosphate)(n) = CMP + (glycerophosphate)(n+1) (according to Swiss-Prot)

• Protein family: CDP-glycerol glycerophosphotransferase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot), membrane associated PubMed

Database entries

• Structure:

• UniProt: P13485

• KEGG entry: [3]

• E.C. number: 2.7.8.12

Expression and regulation

• Operon: tagD-tagE-tagF PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed by phosphate (PhoP) PubMed

• Regulatory mechanism:
  • PhoP: transcription repression PubMed
  • WalR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

<pubmed>18156271,16141206 2507871 ,12637499,1712357,9457886,18763711, 19520862 7581998 12950927 15547257 </pubmed>