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| =The PEP:Sugar Phosphotransferase System=
| | #REDIRECT [[phosphotransferase systems]] |
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| '''The PTS is a sugar transport system that couples the transport of a sugar to its phosphorylation. The phosphate group is derived from phosphoenolpyruvate (PEP) and transferred via the general PTS proteins [[ptsI|Enzyme I]] ([[ptsI|EI]]) and [[ptsH|HPr]] to the substrate-specific Enzymes II (EII) to the incoming sugars.'''
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| '''In addition to its role in sugar transport, the PTS is also involved in the regulation of carbon metabolism.'''
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| ==General PTS proteins==
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| * [[ptsI|Enzyme I]]
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| * [[ptsH|HPr]]
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| ==Sugar specific PTS proteins==
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| * [[PtsG]]: glucose permease, EIICBA
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| * [[GamP]]: glucosamine permease, EIICBA
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| * [[MurP]]: N-acetyl muramic acid-specific phosphotransferase system, EIIBC component
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| * [[MtlA]], [[MtlF]]: mannitol permease
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| * [[GmuA]], [[GmuB]], [[GmuC]]: galactomannan permease
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| * [[TreP]]: trehalose permease
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| * [[MalP]]: maltose permease
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| * [[FruA]]: fructose permease
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| * [[ManP]]: mannose permease
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| * [[NagP]]: N-acetylglucosamine permease, EIICB component
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| * [[LevD]], [[LevE]], [[LevF]], [[LevG]]: fructose permease
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| * [[SacP]]: sucrose permease (high affinity)
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| * [[SacY]]: sucrose permease (low affinity)
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| * [[LicA]], [[LicB]], [[LicC]]: lichenan permease
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| * [[BglP]]: ß-glucoside permease
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| * [[YpqE]]: unknown EIIA component
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| * [[YwbA]]: unknown EIIC component
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| * [[YyzE]]: unknown PTS protein
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| ==Proteins closely related to the PTS==
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| * [[Crh]]: [[ptsH|HPr]]-like protein with exculsively regulatory functions (His-15 is not conserved
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| * [[HprK]]: [[ptsH|HPr]]-kinase, key factor for carbon catabolite repression
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| ==Non-PTS proteins controlled by PTS-dependent phosphorylation==
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| * [[PRD-containing transcription factors]]
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| * [[GlpK]]
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| ==The PTS in [[SubtiPathways|''Subti''Pathways]]==
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| * [http://subtiwiki.uni-goettingen.de/pathways/carbon_flow.html Central C-metabolism]
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| * [http://subtiwiki.uni-goettingen.de/pathways/carbohydrate_metabolic_pathways.html Sugar catabolism]
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| ==Related Lists==
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| * [[PRD-containing transcription factors]]
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| * [[transport proteins]]
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| * [[trigger enzymes]]
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| ==Relevant Reviews==
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| <pubmed>17158705 9871918 9663674 10627040 11532441 16339738 </pubmed>
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