Two-component systems: Difference between revisions
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Two component systems are signal transduction systems that consist of a sensor kinase and a response regulator (usually a [[transcription factors|transcription factor]]). The kinase autophosphorylates on a His residue (more preciely, one subunit of the dimeric kinase phosphorylates the His residue of the other subunit), and the phosphate group can then be transferred to an aspartate residue in the cognate response regulator. Some response regulators can also autophosphorylate using acety-phosphate as the phosphate donor. | Two component systems are signal transduction systems that consist of a sensor kinase and a response regulator (usually a [[transcription factors|transcription factor]]). The kinase autophosphorylates on a His residue (more preciely, one subunit of the dimeric kinase phosphorylates the His residue of the other subunit), and the phosphate group can then be transferred to an aspartate residue in the cognate response regulator. Some response regulators can also autophosphorylate using acety-phosphate as the phosphate donor. | ||
More complex signal transduction systems of this class are called phosphorelay. The paradigm for a phosphorelay is the pathway leading to the phosphorylation of [[Spo0A]]. | More complex signal transduction systems of this class are called [[phosphorelay]]. The paradigm for a [[phosphorelay]] is the pathway leading to the phosphorylation of [[Spo0A]]. | ||
==Two-component systems in ''B. subtilis'' (kinase, regulator)== | ==Two-component systems in ''B. subtilis'' (kinase, regulator)== | ||
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** [[LytS]], [[LytT]] | ** [[LytS]], [[LytT]] | ||
** [[YesM]], [[YesN]] | ** [[YesM]], [[YesN]] | ||
** [[YwpD]] (orphan) | ** [[YwpD]] (orphan kinase) | ||
==The phosphorelay== | ==The [[phosphorelay]]== | ||
* Kinases | * Kinases | ||
** [[KinA]] | ** [[KinA]] | ||
Revision as of 09:39, 28 November 2009
Two component systems are signal transduction systems that consist of a sensor kinase and a response regulator (usually a transcription factor). The kinase autophosphorylates on a His residue (more preciely, one subunit of the dimeric kinase phosphorylates the His residue of the other subunit), and the phosphate group can then be transferred to an aspartate residue in the cognate response regulator. Some response regulators can also autophosphorylate using acety-phosphate as the phosphate donor. More complex signal transduction systems of this class are called phosphorelay. The paradigm for a phosphorelay is the pathway leading to the phosphorylation of Spo0A.
Two-component systems in B. subtilis (kinase, regulator)
- NarL-family
- OmpR family
The phosphorelay
- The ultimate target
Reviews
<pubmed>17338439 19575571 11406410 10966457 10932244 17158704 10094672 11489844 </pubmed>