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| * '''Description:''' transcriptional antiterminator of the ''pyr'' operon <br/><br/>
| | {{#bank: PyrR}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''pyrR''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || transcriptional antiterminator with minor uracil<br/> phosphoribosyltransferase activity
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| |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of pyrimidine biosynthesis
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/pyrimidines_metabolism.html Pyrimidines], [http://subtiwiki.uni-goettingen.de/pathways/gene_regulation_nucleotides.html Nucleotides (regulation)]'''
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 20 kDa, 4.991
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 543 bp, 181 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ylyB]]'', ''[[pyrP]]''
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| |colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB13421]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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| |colspan="2" | '''Genetic context''' <br/> [[Image:pyrR_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |}
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| __TOC__
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| <br/><br/><br/><br/><br/><br/>
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU15470
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/pyrRPBCAAABKDFE.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10712]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)
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| * '''Protein family:''' PyrR subfamily (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''Interactions:''' [[PyrR]]-[[PyrR]]
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| * '''Localization:'''
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| === Database entries ===
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| * '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=1A3C 1A3C] (dimeric form)
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| * '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/P39765 P39765]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu+BSU15470]
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| * '''E.C. number:''' [http://www.expasy.org/enzyme/2.4.2.9 2.4.2.9]
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[pyrR]]-[[pyrP]]-[[pyrB]]-[[pyrC]]-[[pyrAA]]-[[pyrAB]]-[[pyrK]]-[[pyrD]]-[[pyrF]]-[[pyrE]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/8206849 PubMed]
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| * '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/1709162 PubMed]
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| * '''Regulation:'''
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| ** induced in the absence of uridine nucleotides ([[PyrR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8206849 PubMed]
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| * '''Regulatory mechanism:'''
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| ** [[PyrR]]: [[RNA switch]], transcription termination/ antitermination (in the presence of uridine nucleotides: termination, in their absence: antitermination) [http://www.ncbi.nlm.nih.gov/sites/entrez/8955403 PubMed]
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>8935652,8206849,15716449,11726695,9488732,9551555,12896995,9932459,8955403,8824632,12482852,1709162,7798145,11948166,8759868,7868607,9551555 9488732, </pubmed>
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