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| * '''Description:''' is the main controling enzyme of the glycolysis. Phosphorylates fructose 6-phosphate to fructose 1,3-bisphosphate <br/><br/>
| | {{#bank: PfkA}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''pfkA''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''pfk''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || yes
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| |style="background:#ABCDEF;" align="center"| '''Product''' || 6-phosphofructokinase
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| |style="background:#ABCDEF;" align="center"|'''Function''' || phosphorylation of fructose 6-phosphat
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 34,1 kDa, 6.14
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 957 bp, 319 amino acids
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[accA]]'', ''[[pyk]]''
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| |style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/genE_nucleotide.txt Gene sequence (+200bp) ]'''
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| |style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/genE_protein.txt Protein sequence]'''
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| |colspan="2" | '''Genetic context''' <br/> [[Image:genE_context.gif]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/><br/><br/><br/><br/><br/><br/>
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| =The gene=
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| === Basic information ===
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| * '''Coordinates:'''
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/pfkA-pyk-ytzA.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG12644]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate
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| * '''Protein family:''' phosphofructokinase family
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| ** 3 x nucleotide binding domain (ATP) (21–25), (154–158), (171–187)
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| * '''Modification:'''
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| * '''Cofactor(s):''' ATP
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| * '''Effectors of protein activity:'''
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| * '''Interactions:'''
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| * '''Localization:''' Cytoplasm
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| === Database entries ===
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| * '''Structure:''' ''Geobacillus stearothermophilus'' [http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?Dopt=s&uid=58449 NCBI], Mutan, complex with Fructose-6-phosphate ''Geobacillus stearothermophilus'' [http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?Dopt=s&uid=21480 NCBI]
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| * '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/O34529]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU29190]
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| * '''E.C. number:''' [http://www.expasy.org/enzyme/2.7.1.11]
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:'''
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| * '''Sigma factor:'''
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| * '''Regulation:''' induced by Glucose
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| * '''Regulatory mechanism:'''
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| * '''Additional information:'''
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| =Biological materials =
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| # Author1, Author2 & Author3 (year) Title ''Journal'' '''volume:''' page-page. [http://www.ncbi.nlm.nih.gov/sites/entrez/PMID PubMed]
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