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#REDIRECT [[CodW]]
* '''Description:''' two-component ATP-dependent protease <br/><br/>
 
{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''clpQ ''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''hslV, codW''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || two-component ATP-dependent protease
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || protein degradation
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU16150 clpQ]
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=ClpQ ClpQ]
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 19 kDa, 6.105 
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 543 bp, 181 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[codV]]'', ''[[clpY]]''
|-
|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU16150 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU16150 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU16150 DNA_with_flanks]
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:clpQ_context.gif]]
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=clpQ_1688114_1688659_1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:clpQ_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU16150]]
|-
|}
 
__TOC__
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= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[proteolysis]]}},
{{SubtiWiki category|[[membrane proteins]]}}
 
= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[CodY regulon]]}}
 
=The gene=
 
=== Basic information ===
 
* '''Locus tag:''' BSU16150
 
===Phenotypes of a mutant ===
 
=== Database entries ===
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU16150&redirect=T BSU16150]
 
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/codV-clpQY-codY.html]
 
* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10966]
 
=== Additional information===
 
 
 
 
=The protein=
 
=== Basic information/ Evolution ===
 
* '''Catalyzed reaction/ biological activity:'''
 
* '''Protein family:''' HslV subfamily (according to Swiss-Prot)
 
* '''Paralogous protein(s):'''
 
=== Extended information on the protein ===
 
* '''Kinetic information:'''
 
* '''Domains:'''
 
* '''Modification:'''
 
* '''Cofactor(s):'''
 
* '''Effectors of protein activity:'''
 
* '''[[SubtInteract|Interactions]]:'''
** [[ClpQ]]-[[ClpY]] {{PubMed|18689473}}
 
* '''[[Localization]]:'''
** cytoplasm, forms small foci, usually positioned near the cell membrane, formation of foci depends on the presence of the cognate ATPase [[ClpY]] {{PubMed|18689473}}
 
=== Database entries ===
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU16150&redirect=T BSU16150]
 
* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2Z3B 2Z3B]
 
* '''UniProt:''' [http://www.uniprot.org/uniprot/P39070 P39070]
 
* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU16150]
 
* '''E.C. number:'''
 
=== Additional information===
 
=Expression and regulation=
 
* '''Operon:''' ''[[codV]]-[[clpQ]]-[[clpY]]-[[codY]]'' {{PubMed|7783641}}
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=clpQ_1688114_1688659_1 clpQ] {{PubMed|22383849}}
 
* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|7783641}}
 
* '''Regulation:'''
** repressed during growth in the presence of branched chain amino acids ([[CodY]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/11331605 PubMed]
 
* '''Regulatory mechanism:'''
** [[CodY]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/11331605 PubMed]
 
* '''Additional information:'''
 
=Biological materials =
 
* '''Mutant:'''
 
* '''Expression vector:'''
       
* '''lacZ fusion:'''
 
* '''GFP fusion:'''
 
* '''two-hybrid system:'''
 
* '''Antibody:'''
 
=Labs working on this gene/protein=
 
=Your additional remarks=
 
=References=
==Reviews==
'''Additional reviews:''' {{PubMed|23479438}}
==Original publications==
<pubmed>12805205,11179218,18689473,11331605, 7783641</pubmed>
 
[[Category:Protein-coding genes]]

Latest revision as of 13:43, 2 April 2014

  • Description: two-component ATP-dependent protease

Gene name clpQ
Synonyms hslV, codW
Essential no
Product two-component ATP-dependent protease
Function protein degradation
Gene expression levels in SubtiExpress: clpQ
Interactions involving this protein in SubtInteract: ClpQ
MW, pI 19 kDa, 6.105
Gene length, protein length 543 bp, 181 aa
Immediate neighbours codV, clpY
Sequences Protein DNA DNA_with_flanks
Genetic context
This image was kindly provided by SubtiList
Expression at a glance   PubMed















Categories containing this gene/protein

proteolysis, membrane proteins

This gene is a member of the following regulons

CodY regulon

The gene

Basic information

  • Locus tag: BSU16150

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: HslV subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:
    • cytoplasm, forms small foci, usually positioned near the cell membrane, formation of foci depends on the presence of the cognate ATPase ClpY PubMed

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Additional reviews: PubMed

Original publications

<pubmed>12805205,11179218,18689473,11331605, 7783641</pubmed>

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