T-box: Difference between revisions
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In the absence of an amino acid, the uncharged tRNA binds the T-box region in the leader region of the mRNA of the controlled gene/ operon and thereby prevents the formation of a transcription terminator. The result is gene expression of the target gene in the absence of the specific amino acid. | In the absence of an amino acid, the uncharged tRNA binds the T-box region in the leader region of the mRNA of the controlled gene/ operon and thereby prevents the formation of a transcription terminator. The result is gene expression of the target gene in the absence of the specific amino acid. | ||
== | ==Complete list of genes controlled by T-box elements== | ||
* Induction by alanine limitation | * Induction by alanine limitation | ||
| Line 24: | Line 24: | ||
* Induction by leucine limitation | * Induction by leucine limitation | ||
** ''[[leuS]]'', ''[[ilvB]]-[[ilvH]]-[[ilvC]]-[[leuA]]-[[leuA]]-[[leuC]]-[[leuD | ** ''[[leuS]]'', ''[[ilvB]]-[[ilvH]]-[[ilvC]]-[[leuA]]-[[leuA]]-[[leuC]]-[[leuD]]'', ''[[yvbW]]'' | ||
* Induction by phenyalanine limitation | * Induction by phenyalanine limitation | ||
** ''[[pheS]]-[[pheT]]'' | ** ''[[pheS]]-[[pheT]]'' | ||
* Induction by proline limitation | |||
** ''[[proB]]-[[proA]]'', ''[[proI]]'' | |||
* Induction by serine limitation | * Induction by serine limitation | ||
** ''[[serS]]'' | ** ''[[serS]]'' | ||
* Induction by threonine limitation | * Induction by threonine limitation | ||
** ''[[thrS]], [[thrZ]]'' | ** ''[[thrS]], [[thrZ]]-[[ywhA]]'' | ||
* Induction by tryptophan limitation | * Induction by tryptophan limitation | ||
| Line 46: | Line 46: | ||
* Induction by valine limitation | * Induction by valine limitation | ||
** ''[[valS]]'', ''[[ilvB]]-[[ilvH]]-[[ilvC]]-[[leuA]]-[[leuA]]-[[leuC]]-[[leuD]]'' | ** ''[[valS]]'', ''[[ilvB]]-[[ilvH]]-[[ilvC]]-[[leuA]]-[[leuA]]-[[leuC]]-[[leuD]]'' | ||
==Structure of a T-box ribowsitch== | |||
<pubmed>28621923 12547201 31740854 </pubmed> | |||
==Reviews on T-box regulation== | ==Reviews on T-box regulation== | ||
<pubmed> 19258532,7527891, 8348614,17381302 </pubmed> | <pubmed> 19258532,7527891, 11917026 ,8348614,17381302 10546897 19932103 18625071 24954903 24816551 32882008</pubmed> | ||
=See also:= | |||
* [[RNA switch]] | |||
=Back to [[regulons]]= | |||
Latest revision as of 08:40, 5 January 2021
The T-box element is an RNA switch that controls genes involved in amino acid metabolism.
In the absence of an amino acid, the uncharged tRNA binds the T-box region in the leader region of the mRNA of the controlled gene/ operon and thereby prevents the formation of a transcription terminator. The result is gene expression of the target gene in the absence of the specific amino acid.
Complete list of genes controlled by T-box elements
- Induction by alanine limitation
- Induction by serine limitation
Structure of a T-box ribowsitch
<pubmed>28621923 12547201 31740854 </pubmed>
Reviews on T-box regulation
<pubmed> 19258532,7527891, 11917026 ,8348614,17381302 10546897 19932103 18625071 24954903 24816551 32882008</pubmed>