Latest revision as of 12:59, 4 February 2015

Description: toxic peptide

Gene name	txpA
Synonyms	yqcR, yqdB
Essential	no
Product	toxic peptide
Function	toxin
*Gene expression levels in SubtiExpress*: txpA
MW, pI	6 kDa, 8.139
Gene length, protein length	177 bp, 59 aa
Immediate neighbours	yqbN/2, ratA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance PubMed

Categories containing this gene/protein

toxins, antitoxins and immunity against toxins, Skin element, membrane proteins

This gene is a member of the following regulons

ratA regulon

The gene

Basic information

Locus tag: BSU26050

Phenotypes of a mutant

Database entries

BsubCyc: BSU26050

DBTBS entry: [1]

SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

Catalyzed reaction/ biological activity:

Protein family:

Paralogous protein(s):

Extended information on the protein

Kinetic information:

Domains:

Modification:

Cofactor(s):

Effectors of protein activity:

Interactions:

Localization:
- cell membrane

Database entries

BsubCyc: BSU26050

Structure:

UniProt: P54373

KEGG entry: [3]

E.C. number:

Additional information

Expression and regulation

Operon: txpA PubMed

Expression browser: txpA PubMed

Sigma factor: SigA PubMed

Regulation:

Regulatory mechanism:
- expression is prevented by the ratA antisense RNA PubMed
- the txpA mRNA-RatA RNA duplex is degraded by RNase III PubMed

Additional information:
- next to yonT, the txpA mRNA has the strongest Shine-Dalgarno region in B. subtilis PubMed

Biological materials

Mutant:

Expression vector:

lacZ fusion:

GFP fusion:

two-hybrid system:

Antibody:

Labs working on this gene/protein

Richard Losick, Harvard University, Cambridge, USA Homepage

Your additional remarks

References

Reviews

Original publications

@@ Line 1: / Line 1: @@
-#REDIRECT [[YqcR]]
+* '''Description:''' toxic peptide <br/><br/>
+{| align="right" border="1" cellpadding="2"
+|-
+|style="background:#ABCDEF;" align="center"|'''Gene name'''
+|''txpA ''
+|-
+|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yqcR, yqdB''
+|-
+|style="background:#ABCDEF;" align="center"| '''Essential''' || no
+|-
+|style="background:#ABCDEF;" align="center"| '''Product''' || toxic peptide
+|-
+|style="background:#ABCDEF;" align="center"|'''Function''' || toxin
+|-
+|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU26050 txpA]
+|-
+|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 6 kDa, 8.139
+|-
+|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 177 bp, 59 aa
+|-
+|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yqbN/2]]'', ''[[ratA]]''
+|-
+|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU26050 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU26050 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU26050 DNA_with_flanks]
+|-
+|colspan="2" | '''Genetic context''' <br/> [[Image:yqdB_context.gif]]
+ <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
+|-
+|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yqdB_2678240_2678419_1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:txpA_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU26050]]
+|-
+|}
+__TOC__
+<br/><br/><br/><br/>
+<br/><br/><br/><br/>
+<br/><br/><br/><br/>
+<br/><br/>
+= [[Categories]] containing this gene/protein =
+{{SubtiWiki category|[[toxins, antitoxins and immunity against toxins]]}},
+{{SubtiWiki category|[[Skin element]]}},
+{{SubtiWiki category|[[membrane proteins]]}}
+= This gene is a member of the following [[regulons]] =
+{{SubtiWiki regulon|[[ratA regulon]]}}
+=The gene=
+=== Basic information ===
+* '''Locus tag:''' BSU26050
+===Phenotypes of a mutant ===
+=== Database entries ===
+* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU26050&redirect=T BSU26050]
+* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/txpA.html]
+* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11512]
+=== Additional information===
+=The protein=
+=== Basic information/ Evolution ===
+* '''Catalyzed reaction/ biological activity:'''
+* '''Protein family:'''
+* '''Paralogous protein(s):'''
+=== Extended information on the protein ===
+* '''Kinetic information:'''
+* '''Domains:'''
+* '''Modification:'''
+* '''Cofactor(s):'''
+* '''Effectors of protein activity:'''
+* '''[[SubtInteract|Interactions]]:'''
+* '''[[Localization]]:'''
+** cell membrane
+=== Database entries ===
+* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU26050&redirect=T BSU26050]
+* '''Structure:'''
+* '''UniProt:''' [http://www.uniprot.org/uniprot/P54373 P54373]
+* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU26050]
+* '''E.C. number:'''
+=== Additional information===
+=Expression and regulation=
+* '''Operon:''' ''txpA'' [http://www.ncbi.nlm.nih.gov/sites/entrez/16166525 PubMed]
+* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yqdB_2678240_2678419_1 txpA] {{PubMed|22383849}}
+* '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/16166525 PubMed]
+* '''Regulation:'''
+* '''Regulatory mechanism:'''
+** expression is prevented by the ''[[ratA]]'' antisense RNA [http://www.ncbi.nlm.nih.gov/sites/entrez/16166525 PubMed]
+** the ''[[txpA]]'' mRNA-''[[RatA]]'' RNA duplex is degraded by [[rnc|RNase III]] {{PubMed|23300471}}
+* '''Additional information:'''
+** next to ''[[yonT]]'', the ''[[txpA]]'' mRNA has the strongest Shine-Dalgarno region in ''B. subtilis'' {{PubMed|19210617}}
+=Biological materials =
+* '''Mutant:'''
+* '''Expression vector:'''
+* '''lacZ fusion:'''
+* '''GFP fusion:'''
+* '''two-hybrid system:'''
+* '''Antibody:'''
+=Labs working on this gene/protein=
+[[Richard Losick]], Harvard University, Cambridge, USA [http://www.mcb.harvard.edu/Losick/ Homepage]
+=Your additional remarks=
+=References=
+==Reviews==
+<pubmed> 23300472 </pubmed>
+==Original publications==
+<pubmed>16166525, 19210617 23300471</pubmed>
+[[Category:Protein-coding genes]]