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''[[cysE]]'' | The T-box element is an [[RNA switch]] that controls genes involved in amino acid metabolism. | ||
In the absence of an amino acid, the uncharged tRNA binds the T-box region in the leader region of the mRNA of the controlled gene/ operon and thereby prevents the formation of a transcription terminator. The result is gene expression of the target gene in the absence of the specific amino acid. | |||
==Complete list of genes controlled by T-box elements== | |||
* Induction by alanine limitation | |||
** ''[[alaS]]'' | |||
* Induction by aspartate limitation | |||
** ''[[hisS]]-[[aspS]]'' | |||
* Induction by cysteine limitation | |||
** ''[[cysE]]-[[cysS]]-[[mrnC]]-[[yacO]]-[[yacP]]'' | |||
* Induction by glycine limitation | |||
** ''[[glyA]], [[glyQ]]-[[glyS]]'' | |||
* Induction by histidine limitation | |||
** ''[[hisS]]-[[aspS]]'' | |||
* Induction by isoleucine limitation | |||
** ''[[ileS]]'', ''[[ilvB]]-[[ilvH]]-[[ilvC]]-[[leuA]]-[[leuA]]-[[leuC]]-[[leuD]]'' | |||
* Induction by leucine limitation | |||
** ''[[leuS]]'', ''[[ilvB]]-[[ilvH]]-[[ilvC]]-[[leuA]]-[[leuA]]-[[leuC]]-[[leuD]]'', ''[[yvbW]]'' | |||
* Induction by phenyalanine limitation | |||
** ''[[pheS]]-[[pheT]]'' | |||
* Induction by proline limitation | |||
** ''[[proB]]-[[proA]]'', ''[[proI]]'' | |||
* Induction by serine limitation | |||
** ''[[serS]]'' | |||
* Induction by threonine limitation | |||
** ''[[thrS]], [[thrZ]]-[[ywhA]]'' | |||
* Induction by tryptophan limitation | |||
** ''[[rtpA]]-[[ycbK]]'', ''[[trpS]]'' | |||
* Induction by tyrosine limitation | |||
** ''[[tyrS]], [[tyrZ]]'' | |||
* Induction by valine limitation | |||
** ''[[valS]]'', ''[[ilvB]]-[[ilvH]]-[[ilvC]]-[[leuA]]-[[leuA]]-[[leuC]]-[[leuD]]'' | |||
==Structure of a T-box ribowsitch== | |||
<pubmed>28621923 12547201 31740854 </pubmed> | |||
==Reviews on T-box regulation== | |||
<pubmed> 19258532,7527891, 11917026 ,8348614,17381302 10546897 19932103 18625071 24954903 24816551 32882008</pubmed> | |||
=See also:= | |||
* [[RNA switch]] | |||
=Back to [[regulons]]= | |||
Latest revision as of 08:40, 5 January 2021
The T-box element is an RNA switch that controls genes involved in amino acid metabolism.
In the absence of an amino acid, the uncharged tRNA binds the T-box region in the leader region of the mRNA of the controlled gene/ operon and thereby prevents the formation of a transcription terminator. The result is gene expression of the target gene in the absence of the specific amino acid.
Complete list of genes controlled by T-box elements
- Induction by alanine limitation
- Induction by serine limitation
Structure of a T-box ribowsitch
<pubmed>28621923 12547201 31740854 </pubmed>
Reviews on T-box regulation
<pubmed> 19258532,7527891, 11917026 ,8348614,17381302 10546897 19932103 18625071 24954903 24816551 32882008</pubmed>