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New page: * '''Description:''' write here <br/><br/> {| align="right" border="1" cellpadding="2" |- |style="background:#ABCDEF;" align="center"|'''Gene name''' |''yolJ'' |- |style="background:#ABC...
 
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* '''Description:''' write here <br/><br/>
{{#bank: sunS}}
* '''Description:''' sublancin S-glycosyltransferase <br/><br/>


{| align="right" border="1" cellpadding="2"  
{| align="right" border="1" cellpadding="2"  
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|style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
|-
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' ||  
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|-
|style="background:#ABCDEF;" align="center"| '''Product''' ||  
|style="background:#ABCDEF;" align="center"| '''Product''' || sublancin S-glycosyltransferase
|-
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || unknown
|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of the antimicrobial peptide sublancin
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU21450 sunS]
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in  [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=SunS SunS]'''
|-
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 49 kDa, 5.33   
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 49 kDa, 5.33   
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|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1266 bp, 422 aa  
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1266 bp, 422 aa  
|-
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' ||  
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[bdbB]]'', ''[[bdbA]]''
|-
|-
|style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/yolJ_nucleotide.txt    Gene sequence     (+200bp)  ]'''
|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU21450 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU21450 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU21450 DNA_with_flanks]
|style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/yolJ_protein.txt Protein sequence]'''
|-
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:yolJ_context.gif]]
|colspan="2" | '''Genetic context''' <br/> [[Image:yolJ_context.gif]]
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yolJ_2265668_2266936_-1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:sunS_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU21450]]
|-
|-
|}
|}


__TOC__
__TOC__
<br/><br/><br/><br/>
<br/><br/><br/><br/>
<br/><br/><br/><br/>
<br/><br/>


<br/><br/>
= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[SP-beta prophage]]}},
{{SubtiWiki category|[[membrane proteins]]}},
{{SubtiWiki category|[[protein modification]]}},
{{SubtiWiki category|[[biosynthesis of antibacterial compounds]]}}
 
= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[Abh regulon]]}},
{{SubtiWiki regulon|[[AbrB regulon]]}},
{{SubtiWiki regulon|[[Rok regulon]]}},
{{SubtiWiki regulon|[[YvrHb regulon]]}}


=The gene=
=The gene=
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=== Basic information ===
=== Basic information ===


* '''Coordinates:'''
* '''Locus tag:''' BSU21450


===Phenotypes of a mutant ===
===Phenotypes of a mutant ===


=== Database entries ===
=== Database entries ===
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU21450&redirect=T BSU21450]


* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yolJ.html]
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/sunT-bdbA-yolJ-bdbB.html]


* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13586]
* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13586]


=== Additional information===
=== Additional information===




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* '''Catalyzed reaction/ biological activity:'''  
* '''Catalyzed reaction/ biological activity:'''  
** selectively modifies Cys22 in a 56-amino acid peptide substrate [[SunA]] and can accept a variety of NDP-sugars {{PubMed|21196935}}


* '''Protein family:'''
* '''Protein family:''' EngA subfamily (according to Swiss-Prot)


* '''Paralogous protein(s):'''
* '''Paralogous protein(s):'''
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* '''Effectors of protein activity:'''
* '''Effectors of protein activity:'''


* '''Interactions:'''
* '''[[SubtInteract|Interactions]]:'''


* '''Localization:'''
* '''[[Localization]]:''' cell membrane (according to Swiss-Prot)


=== Database entries ===
=== Database entries ===
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU21450&redirect=T BSU21450]


* '''Structure:'''
* '''Structure:'''


* '''Swiss prot entry:'''
* '''UniProt:''' [http://www.uniprot.org/uniprot/O31986 O31986]


* '''KEGG entry:'''
* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU21450]


* '''E.C. number:'''
* '''E.C. number:'''
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=Expression and regulation=
=Expression and regulation=


* '''Operon:'''  
* '''Operon:''' ''[[sunT]]-[[bdbA]]-[[sunS]]-[[bdbB]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/16306698 PubMed]
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yolJ_2265668_2266936_-1 sunS] {{PubMed|22383849}}


* '''Sigma factor:'''  
* '''[[Sigma factor]]:'''  


* '''Regulation:'''  
* '''Regulation:'''  
** repressed by [[Rok]] [http://www.ncbi.nlm.nih.gov/sites/entrez/15743949 PubMed]


* '''Regulatory mechanism:'''  
* '''Regulatory mechanism:'''  
** activated by [[YvrHb]]  [http://www.ncbi.nlm.nih.gov/sites/entrez/16306698 PubMed]
** [[Rok]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/15743949 PubMed]
** [[AbrB]]: transcription repression{{PubMed|20817675}}
** [[Abh]]: transcription activation {{PubMed|20817675}}


* '''Additional information:'''  
* '''Additional information:'''
** the amount of the mRNA is substantially decreased upon depletion of [[Rny|RNase Y]] {{PubMed|21815947}}


=Biological materials =
=Biological materials =
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=References=
=References=
<pubmed>15743949 21196935,20817675,21910430 21815947</pubmed>


# Author1, Author2 & Author3 (year) Title ''Journal'' '''volume:''' page-page. [http://www.ncbi.nlm.nih.gov/sites/entrez/PMID PubMed]
[[Category:Protein-coding genes]]

Latest revision as of 11:36, 4 December 2016

sunS

  • Description: sublancin S-glycosyltransferase

Gene name yolJ
Synonyms
Essential no
Product sublancin S-glycosyltransferase
Function biosynthesis of the antimicrobial peptide sublancin
Gene expression levels in SubtiExpress: sunS
Metabolic function and regulation of this protein in SubtiPathways:
SunS
MW, pI 49 kDa, 5.33
Gene length, protein length 1266 bp, 422 aa
Immediate neighbours bdbB, bdbA
Sequences Protein DNA DNA_with_flanks
Genetic context
This image was kindly provided by SubtiList
Expression at a glance   PubMed















Categories containing this gene/protein

SP-beta prophage, membrane proteins, protein modification, biosynthesis of antibacterial compounds

This gene is a member of the following regulons

Abh regulon, AbrB regulon, Rok regulon, YvrHb regulon

The gene

Basic information

  • Locus tag: BSU21450

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • selectively modifies Cys22 in a 56-amino acid peptide substrate SunA and can accept a variety of NDP-sugars PubMed
  • Protein family: EngA subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Additional information:
    • the amount of the mRNA is substantially decreased upon depletion of RNase Y PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

<pubmed>15743949 21196935,20817675,21910430 21815947</pubmed>

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