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New page: * '''Description:''' write here <br/><br/> {| align="right" border="1" cellpadding="2" |- |style="background:#ABCDEF;" align="center"|'''Gene name''' |''ykuF'' |- |style="background:#ABC...
 
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* '''Description:''' write here <br/><br/>
* '''Description:''' 2,4-dienoyl-CoA reductase <br/><br/>


{| align="right" border="1" cellpadding="2"  
{| align="right" border="1" cellpadding="2"  
|-
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''ykuF''
|''fadH ''
|-
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ykuF''
|-
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' ||  
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|-
|style="background:#ABCDEF;" align="center"| '''Product''' ||  
|style="background:#ABCDEF;" align="center"| '''Product''' || 2,4-dienoyl-CoA reductase
|-
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || unknown
|style="background:#ABCDEF;" align="center"|'''Function''' || fatty acid degradation
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU14060 fadH]
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=fadH fadH]'''
|-
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 26 kDa, 6.495   
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 26 kDa, 6.495   
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|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 762 bp, 254 aa  
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 762 bp, 254 aa  
|-
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' ||  
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ykuE]]'', ''[[fadG]]''
|-
|-
|style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/ykuF_nucleotide.txt    Gene sequence     (+200bp)  ]'''
|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU14060 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU14060 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU14060 DNA_with_flanks]
|style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/ykuF_protein.txt Protein sequence]'''
|-
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:ykuF_context.gif]]
|colspan="2" | '''Genetic context''' <br/> [[Image:ykuF_context.gif]]
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=fadH_1478072_1478836_1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:fadH_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU14060]]
|-
|-
|}
|}


__TOC__
__TOC__
<br/><br/><br/><br/>
<br/><br/><br/><br/>
<br/><br/><br/><br/>
<br/><br/><br/><br/>
<br/><br/><br/><br/>
<br/><br/><br/><br/><br/><br/>
= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[utilization of lipids]]}}


<br/><br/>
= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[FadR regulon]]}}


=The gene=
=The gene=
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=== Basic information ===
=== Basic information ===


* '''Coordinates:'''
* '''Locus tag:''' BSU14060


===Phenotypes of a mutant ===
===Phenotypes of a mutant ===


=== Database entries ===
=== Database entries ===
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU14060&redirect=T BSU14060]


* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/ykuF.html]
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/ykuFG.html]


* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13290]
* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13290]


=== Additional information===
=== Additional information===




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=== Basic information/ Evolution ===
=== Basic information/ Evolution ===


* '''Catalyzed reaction/ biological activity:'''  
* '''Catalyzed reaction/ biological activity:''' Trans-2,3-didehydroacyl-CoA + NADP<sup>+</sup> = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH (according to Swiss-Prot)


* '''Protein family:'''
* '''Protein family:''' 2,4-dienoyl-CoA reductase subfamily (according to Swiss-Prot)


* '''Paralogous protein(s):'''
* '''Paralogous protein(s):'''
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* '''Effectors of protein activity:'''
* '''Effectors of protein activity:'''


* '''Interactions:'''
* '''[[SubtInteract|Interactions]]:'''  


* '''Localization:'''
* '''[[Localization]]:'''


=== Database entries ===
=== Database entries ===
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU14060&redirect=T BSU14060]


* '''Structure:'''
* '''Structure:'''


* '''Swiss prot entry:'''
* '''UniProt:''' [http://www.uniprot.org/uniprot/O34717 O34717]


* '''KEGG entry:'''
* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU14060]


* '''E.C. number:'''
* '''E.C. number:''' [http://www.expasy.org/enzyme/1.3.1.34 1.3.1.34]


=== Additional information===
=== Additional information===
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=Expression and regulation=
=Expression and regulation=


* '''Operon:'''  
* '''Operon:''' ''[[fadH]]-[[fadG]]'' {{PubMed|17189250}}
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=fadH_1478072_1478836_1 fadH] {{PubMed|22383849}}


* '''Sigma factor:'''  
* '''Sigma factor:'''  


* '''Regulation:'''  
* '''Regulation:'''  
** induced in the presence of long-chain fatty acids ([[FadR]]) {{PubMed|17189250}}


* '''Regulatory mechanism:'''  
* '''Regulatory mechanism:'''  
** [[FadR]]: transcription repression {{PubMed|17189250}}


* '''Additional information:'''  
* '''Additional information:'''


=Biological materials =
=Biological materials =
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=References=
=References=


# Author1, Author2 & Author3 (year) Title ''Journal'' '''volume:''' page-page. [http://www.ncbi.nlm.nih.gov/sites/entrez/PMID PubMed]
<pubmed>17189250,17919287</pubmed>
 
[[Category:Protein-coding genes]]

Latest revision as of 13:34, 2 April 2014

  • Description: 2,4-dienoyl-CoA reductase

Gene name fadH
Synonyms ykuF
Essential no
Product 2,4-dienoyl-CoA reductase
Function fatty acid degradation
Gene expression levels in SubtiExpress: fadH
Metabolic function and regulation of this protein in SubtiPathways:
fadH
MW, pI 26 kDa, 6.495
Gene length, protein length 762 bp, 254 aa
Immediate neighbours ykuE, fadG
Sequences Protein DNA DNA_with_flanks
Genetic context
This image was kindly provided by SubtiList
Expression at a glance   PubMed




























Categories containing this gene/protein

utilization of lipids

This gene is a member of the following regulons

FadR regulon

The gene

Basic information

  • Locus tag: BSU14060

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH (according to Swiss-Prot)
  • Protein family: 2,4-dienoyl-CoA reductase subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
    • induced in the presence of long-chain fatty acids (FadR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

<pubmed>17189250,17919287</pubmed>

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