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| * '''Description:''' D-alanine transfer from undecaprenol-phosphate to the poly(glycerophosphate) chain, alanylation of teichoic acid provides some resistance against positively charged antimicrobial peptides <br/><br/>
| | {{#bank: DltD}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''dltD''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ipa-2r ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || D-alanine transfer from undecaprenol-phosphate <br/>to the poly(glycerophosphate) chain
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of teichoic acid
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| |-
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU38530 dltD]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=DltD DltD]'''
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 44 kDa, 9.858
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1176 bp, 392 aa
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[dltC]]'', ''[[dltE]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU38530 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU38530 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU38530 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:dltD_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=dltD_3955223_3956401_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:dltD_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU38530]]
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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|
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[cell wall synthesis]]}},
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| {{SubtiWiki category|[[biosynthesis of cell wall components]]}},
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| {{SubtiWiki category|[[cell envelope stress proteins (controlled by SigM, V, W, X, Y)]]}}
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|
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[SigD regulon]]}},
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| {{SubtiWiki regulon|[[SigM regulon]]}},
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| {{SubtiWiki regulon|[[SigX regulon]]}},
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| {{SubtiWiki regulon|[[Spo0A regulon]]}},
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| {{SubtiWiki regulon|[[stringent response]]}},
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| {{SubtiWiki regulon|[[YvrHb regulon]]}}
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|
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU38530
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| ===Phenotypes of a mutant ===
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| * more sensitive to nisin {{PubMed|23980836}}
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU38530&redirect=T BSU38530]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/dltABCDE.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10548]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:'''
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''[[Domains]]:'''
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| * '''Modification:'''
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| * '''[[Cofactors]]:'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:'''
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU38530&redirect=T BSU38530]
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| * '''Structure:''' [http://www.pdb.org/pdb/explore/explore.do?structureId=3bma 3BMA] (from ''Streptococcus pneumoniae'', 26% identity)
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P39578 P39578]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU38530]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[dltA]]-[[dltB]]-[[dltC]]-[[dltD]]-[[dltE]]'' {{PubMed|7797557}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=dltD_3955223_3956401_1 dltD] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:''' [[SigD]] {{PubMed|7797557}}, [[SigM]] {{PubMed|18179421}}, [[SigX]] {{PubMed|14762009}}
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| * '''Regulation:'''
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| ** [[RelA]] dependent downregulation (Class I) during stringent response {{PubMed|11948165}}
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| ** repressed under conditions that trigger sporulation ([[Spo0A]]) {{PubMed|7797557}}
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| ** expression is reduced in a [[SigV]] mutant {{PubMed|21926231}}
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| * '''Regulatory mechanism:'''
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| ** activated by [[YvrHb]] [http://www.ncbi.nlm.nih.gov/sites/entrez/16306698 PubMed]
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| ** [[Spo0A]]: transcription repression {{PubMed|7797557}}
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| * '''Additional information:'''
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| ** number of protein molecules per cell (minimal medium with glucose and ammonium): 79 {{PubMed|24696501}}
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| ** number of protein molecules per cell (complex medium with amino acids, without glucose): 830 {{PubMed|24696501}}
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| ==Reviews==
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| <pubmed> 24024634 </pubmed>
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| ==Original publications==
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| <pubmed>14762009,17600057,10871614 ,7797557,12850135, 23980836 21856855,21926231</pubmed>
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| [[Category:Protein-coding genes]]
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