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| * '''Description:''' lipoprotein, nutrient receptor, [[germination]] response to L-alanine <br/><br/>
| | {{#bank: GerAC}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''gerAC''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Product''' || nutrient receptor
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| |style="background:#ABCDEF;" align="center"|'''Function''' || [[germination]] response to L-alanine
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| |-
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU33070 gerAC]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=GerAC GerAC]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 42 kDa, 7.302
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1119 bp, 373 aa
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[gerAB]]'', ''[[liaR]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU33070 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU33070 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU33070 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:gerAC_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=gerAC_3393293_3394414_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:gerAC_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU33070]]
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[germination]]}},
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| {{SubtiWiki category|[[membrane proteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[SigF regulon]]}},
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| {{SubtiWiki regulon|[[SigG regulon]]}},
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| {{SubtiWiki regulon|[[SpoVT regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU33070
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU33070&redirect=T BSU33070]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/gerAABC.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10387]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:''' gerABKC lipoprotein family (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''[[Domains]]:'''
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| ** has an N-terminal signal sequence, lipidated on a Cys residue adjacent to the signal peptide {{PubMed|23335419}}
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| * '''Modification:'''
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| * '''[[Cofactors]]:'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[GerAA]]-[[GerAB]]-[[GerAC]] (tentative receptor complex) {{PubMed|21378181,21378197}}
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| ** [[GerAC]] is part of the [[germinosome]] in the spore inner membrane {{PubMed|21696470}}
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| ** [[GerAC]]-[[Lgt]] to fix [[GerAC]] to diacylglycerol in the membrane {{PubMed|15126458}}
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| * '''[[Localization]]:''' cell membrane (according to Swiss-Prot)
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| ** outer surface of the inner spore membrane {{PubMed|23335419,21378181}}
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU33070&redirect=T BSU33070]
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P07870 P07870]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU33070]
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| * '''E.C. number:'''
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| === Additional information===
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| * 1,100 molecules are present per spore {{PubMed|23749970}}
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| =Expression and regulation=
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| * '''Operon:''' ''[[gerAA]]-[[gerAB]]-[[gerAC]]'' {{PubMed|3110007}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=gerAC_3393293_3394414_1 gerAC] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:''' [[SigG]] {{PubMed|15699190}}, [[SigF]] {{PubMed|16497325}}
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| * '''Regulation:'''
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| ** expressed during sporulation in the forespore ([[SigF]], [[SigG]], [[SpoVT]]) {{PubMed|16497325,15699190,8755877}}
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| ** expression level depends on sporulation conditions (medim composition, temperature) {{PubMed|22327596}}
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| * '''Regulatory mechanism:'''
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| ** [[SpoVT]]: transcription repression {{PubMed|8755877}}
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| * '''Additional information:'''
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| ** 1,100 molecules are present per spore {{PubMed|23749970}}
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>3110007,17573930,12670969,2110996,15774895,16497325,16352818, 8755877 21378181,21378197 21696470 15126458 22327596 22493018 23335419 23396907 22343299,16740944, 23749970 24752279</pubmed>
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| [[Category:Protein-coding genes]]
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