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| * '''Description:''' [[two-component systems|two-component]] response regulator, regulation of aerobic and anaerobic respiration <br/><br/>
| | {{#bank: ResD}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''resD''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ypxD ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || [[two-component systems|two-component]] response regulator
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| |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of aerobic and anaerobic respiration <br/>respiration
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU23120 resD]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=ResD ResD]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=resD resD]'''
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 27 kDa, 5.631
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 720 bp, 240 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[resE]]'', ''[[resC]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU23120 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU23120 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU23120 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:resD_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=resD_2417181_2417903_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:resD_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU23120]]
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[regulators of electron transport]]}},
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| {{SubtiWiki category|[[transcription factors and their control]]}},
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| {{SubtiWiki category|[[membrane proteins]]}},
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| {{SubtiWiki category|[[phosphoproteins]]}}
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|
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[CcpA regulon]]}},
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| {{SubtiWiki regulon|[[PhoP regulon]]}},
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| {{SubtiWiki regulon|[[ResD regulon]]}}
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| =The [[ResD regulon]]=
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU23120
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU23120&redirect=T BSU23120]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/resABCDE.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10534]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:''' OmpR family of two-component response regulators
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:''' phosphorylated by [[ResE]] on an Asp residue
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:''' phosphorylation likely affects DNA-binding activity
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| * '''[[SubtInteract|Interactions]]:'''
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| ** ResD interacts with the [[RNA polymerase]] {{PubMed|21710567}}
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| ** [[ResE]]-[[ResD]]
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| * '''[[Localization]]:''' cell membrane (according to Swiss-Prot)
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU23120&redirect=T BSU23120]
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P35163 P35163]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU23120]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon''':
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| ** ''[[resA]]-[[resB]]-[[resC]]-[[resD]]-[[resE]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/8631715 PubMed]
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| ** ''[[resD]]-[[resE]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/8631715 PubMed]
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=resD_2417181_2417903_-1 resD] {{PubMed|22383849}}
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| * '''Sigma factor:'''
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| ** ''[[resA]]'': [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/8631715 PubMed]
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| ** ''[[resD]]'': [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/8631715 PubMed]
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| * '''Regulation:'''
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| ** expressed under anaerobic conditions ([[ResD]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8631715,11222591 PubMed]
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| ** expressed under conditions of phosphate limitation ([[PhoP]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/9988472 PubMed]
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| ** repressed by glucose ([[CcpA]]) {{PubMed|16825793}}
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| * '''Regulatory mechanism:'''
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| ** [[ResD]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/8631715,11222591 PubMed]
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| ** [[PhoP]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/9988472 PubMed]
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| ** [[CcpA]]: transcription repression {{PubMed|16825793}}
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| * '''Additional information:'''
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| ** number of protein molecules per cell (minimal medium with glucose and ammonium): 306 {{PubMed|24696501}}
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| ** number of protein molecules per cell (complex medium with amino acids, without glucose): 3258 {{PubMed|24696501}}
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| ** number of protein molecules per cell (minimal medium with glucose and ammonium, exponential phase): 909 {{PubMed|21395229}}
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| ** number of protein molecules per cell (minimal medium with glucose and ammonium, early stationary phase after glucose exhaustion): 838 {{PubMed|21395229}}
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| ** number of protein molecules per cell (minimal medium with glucose and ammonium, late stationary phase after glucose exhaustion): 969 {{PubMed|21395229}}
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| [[Marion Hulett]], University of Illinois at Chicago, USA [http://www.uic.edu/depts/bios/faculty/hulett/hulettm.shtml Homepage]
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| =Your additional remarks=
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| =References=
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| ==Reviews==
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| <pubmed> 23046954</pubmed>
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| ==Original publications==
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| <pubmed>8682783,15576792,16885274,16885456,11325953,10094672,17322317,8631715,9988472,10972837,10972836,9352926,16825793,8631715,11222591,9988472, 21091510 22287527 21710567</pubmed>
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| [[Category:Protein-coding genes]]
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