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| * '''Description:''' [[two-component systems|two-component]] sensor kinase, detects extracellular [[ComX]] <br/><br/>
| | {{#bank: ComP}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''comP''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Product''' || [[two-component systems|two-component]] sensor kinase
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of [[genetic competence]] and [[quorum sensing]]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU31690 comP]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=ComP ComP]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 89 kDa, 7.997
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 2307 bp, 769 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[comA]]'', ''[[comX]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU31690 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU31690 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU31690 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:comP_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=comP_3253529_3255838_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:comP_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU31690]]
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[genetic competence]]}},
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| {{SubtiWiki category|[[protein modification]]}},
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| {{SubtiWiki category|[[transcription factors and their control]]}},
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| {{SubtiWiki category|[[quorum sensing]]}},
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| {{SubtiWiki category|[[membrane proteins]]}},
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| {{SubtiWiki category|[[phosphoproteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU31690
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| ===Phenotypes of a mutant ===
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| * the mutation suppresses the mucoid phenotype of ''[[motA]]'' or ''[[motB]]'' mutants due to loss of [[DegU]] phosphorylation and concomitant reduced expression of the ''[[capB]]-[[capC]]-[[capA]]-[[capE]]'' operon {{PubMed|24296669}}
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU31690&redirect=T BSU31690]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/comP.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10380]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' autophosphorylation, phosphorylation of [[ComA]]
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| * '''Protein family:'''
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''[[Domains]]:''' eight transmembrane segments
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| * '''Modification:''' autophosphorylation on a His residue
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| * '''[[Cofactors]]:'''
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| * '''Effectors of protein activity:''' [[ComX]] (extracellular)
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[ComP]]-[[ComA]]
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| * '''[[Localization]]:''' cell membrane {{PubMed|18763711}}
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU31690&redirect=T BSU31690]
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/Q99027 Q99027]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU31690]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''comP'' {{PubMed|9274030}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=comP_3253529_3255838_-1 comP] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:'''
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| * '''Regulation:'''
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| * '''Regulatory mechanism:'''
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| ==Reviews==
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| <pubmed>12576575 </pubmed>
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| ==Original Publications==
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| <pubmed>11133937,8643670,12067344,10094672,10419951,2116363,9274030 18763711 24296669 24130811 24425772 </pubmed>
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| [[Category:Protein-coding genes]]
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