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| * '''Description:''' peptide methionine sulfoxide reductase <br/><br/>
| | {{#bank: MsrB}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''msrB''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yppQ''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' ||
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| |style="background:#ABCDEF;" align="center"| '''Product''' || peptide methionine sulfoxide reductase
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| |style="background:#ABCDEF;" align="center"|'''Function''' || regeneration of methionine and<br/> restoration of protein function after oxidative damage
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU21680 msrB]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 16 kDa, 5.842
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 429 bp, 143 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ypqP]]'', ''[[msrA]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU21680 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU21680 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU21680 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:yppQ_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=msrB_2287097_2287528_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:msrB_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU21680]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[resistance against oxidative and electrophile stress]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[Spx regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU21680
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU21680&redirect=T BSU21680]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yppQ.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11628]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' Peptide-L-methionine + thioredoxin disulfide + H<sub>2</sub>O = peptide-L-methionine (R)-S-oxide + thioredoxin (according to Swiss-Prot)
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| * '''Protein family:'''
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:'''
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU21680&redirect=T BSU21680]
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| * '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=1XM0 1XM0]
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P54155 P54155]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU21680]
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| * '''E.C. number:''' [http://www.expasy.org/enzyme/1.8.4.12 1.8.4.12]
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| === Additional information===
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| =Expression and regulation=
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| '''Operon:''' ''[[msrA]]-[[msrB]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/18662407 PubMed]
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=msrB_2287097_2287528_-1 msrB] {{PubMed|22383849}}
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| * '''Sigma factor:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/18662407 PubMed]
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| * '''Regulation:''' induced by oxidative stress ([[Spx]])
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| * '''Regulatory mechanism:''' [[Spx]]: oxidized Spx binds [[RpoA]] and enhances ''[[msrA]]-[[msrB]]'' operon transcription [http://www.ncbi.nlm.nih.gov/sites/entrez/18662407 PubMed]
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>18662407,, </pubmed>
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| [[Category:Protein-coding genes]]
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