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| * '''Description:''' chaperonin, [[universally conserved protein]] <br/><br/>
| | {{#bank: GroES}} |
| {| align="right" border="1" cellpadding="2" | |
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''groES''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Product''' || chaperonin
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || protein folding and re-folding
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| |-
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU06020 groES]
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| |-
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=GroES GroES]
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| |-
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=groES groES]'''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 10 kDa, 4.595
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 282 bp, 94 aa
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ydiL]]'', ''[[groEL]]''
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| |-
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU06020 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU06020 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU06020 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:groES_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |-
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=groES_649903_650187_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:groES_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU06020]]
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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|
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[chaperones/ protein folding]]}},
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| {{SubtiWiki category|[[heat shock proteins]]}},
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| {{SubtiWiki category|[[essential genes]]}},
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| {{SubtiWiki category|[[universally conserved proteins]]}},
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| [[most abundant proteins]]
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|
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[HrcA regulon]]}}
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|
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU06020
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| ===Phenotypes of a mutant ===
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| essential [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU06020&redirect=T BSU06020]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/groESL.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10422]
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| === Additional information===
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|
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:''' groES chaperonin family (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''[[Domains]]:'''
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| * '''Modification:''' phosphorylated on Ser-36 {{PubMed|20509597}}
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| * '''[[Cofactors]]:'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[GroEL]]-[[GroES]]
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| * '''[[Localization]]:''' cytoplasm (according to Swiss-Prot)
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|
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU06020&redirect=T BSU06020]
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P28599 P28599]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU06020]
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| * '''E.C. number:'''
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| === Additional information===
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| [[universally conserved protein]]
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|
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| =Expression and regulation=
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| * '''Operon:''' ''[[groES]]-[[groEL]]'' {{PubMed|1350777}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=groES_649903_650187_1 groES] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|1350776}}
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| * '''Regulation:''' induced by heat shock ([[HrcA]]) {{PubMed|1350777,8576042}}
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| * '''Regulatory mechanism:''' [[HrcA]]: transcription repression {{PubMed|8576042}}
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| * '''Additional information:'''
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| ** belongs to the 100 [[most abundant proteins]] {{PubMed|15378759}}
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| [[Wolfgang Schumann]], Bayreuth University, Germany [http://www.genetik.uni-bayreuth.de/LSGenetik1/schumann_research.htm Homepage]
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| =Your additional remarks=
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| =References=
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| <pubmed>1350777,1350776 ,8576042 7592421 20509597 15378759</pubmed>
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| [[Category:Protein-coding genes]]
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