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| * '''Description:''' bacilliredoxin <br/><br/>
| | {{#bank: BrxA}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''brxA''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' yphP''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || bacilliredoxin
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| |style="background:#ABCDEF;" align="center"|'''Function''' || de-bacillithiolation of S-bacillithiolated [[OhrR]] and [[MetE]]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU21860 brxA]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=BrxA BrxA]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 15 kDa, 4.619
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 432 bp, 144 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ypiP]]'', ''[[ilvD]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU21860 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU21860 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU21860 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:yphP_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yphP_2300221_2300655_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:yphP_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU21860]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[resistance against oxidative and electrophile stress]]}}
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| = This gene is a member of the following [[regulons]] =
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU21860
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yphP.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11614]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| ** de-bacillithiolation of S-bacillithiolated [[OhrR]] and [[MetE]] {{PubMed|24313874}}
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| * '''Protein family:''' scpA family (according to Swiss-Prot)
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| * '''Paralogous protein(s):''' [[BrxB]]
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''[[Domains]]:''' contains an CxC redox motif [http://www.ncbi.nlm.nih.gov/pubmed/20308541]
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| * '''Modification:'''
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| ** S-bacillithiolation upon hypochlorite stress on Cys-53 {{PubMed|21749987}}
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| * '''[[Cofactors]]:'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[BrxA]]-[[MetE]] {{PubMed|24313874}}
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| ** [[BrxA]]-[[OhrR]] {{PubMed|24313874}}
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| * '''[[Localization]]:'''
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| === Database entries ===
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| * '''Structure:''' [http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=3FHK 3FHK] {{PubMed|19653655}}
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P54170 P54170]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU21860]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''brxA'' (according to [http://dbtbs.hgc.jp/COG/prom/yphP.html DBTBS])
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yphP_2300221_2300655_-1 brxA] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:'''
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| * '''Regulation:'''
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| * '''Regulatory mechanism:'''
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| [[YpdA]], [[BrxA]], [[BrxB]] and [[YtxJ]] co-occur in those species predicted to synthesize bacillithiol.
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| =References=
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| <pubmed> 22938038,19653655 20308541 21749987 24313874 </pubmed>
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| [[Category:Protein-coding genes]]
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