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| * '''Description:''' competence pheromone precursor, transfers cell density signal to [[ComP]]; triggers the production of surfactin <br/><br/>
| | {{#bank: ComX}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''comX''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || competence pheromone precursor
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| |style="background:#ABCDEF;" align="center"|'''Function''' || [[quorum sensing]]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU31700 comX]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=ComX ComX]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 6 kDa, 4.358
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 165 bp, 55 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[comP]]'', ''[[comQ]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU31700 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU31700 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU31700 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:comX_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=comX_3255853_3256020_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:comX_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU31700]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[genetic competence]]}},
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| {{SubtiWiki category|[[quorum sensing]]}}
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| = This gene is a member of the following [[regulons]] =
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU31700
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| ===Phenotypes of a mutant ===
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| * the mutation suppresses the mucoid phenotype of ''[[motA]]'' or ''[[motB]]'' mutants due to loss of [[DegU]] phosphorylation and concomitant reduced expression of the ''[[capB]]-[[capC]]-[[capA]]-[[capE]]'' operon {{PubMed|24296669}}
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/comQX.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11324]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:'''
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''[[Domains]]:'''
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| * '''Modification:'''
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| ** is synthesized as an inactive precursor, cleaved, and modified (prenylated) by [[ComQ]] prior to excretion {{PubMed|22878193}}
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| * '''[[Cofactors]]:'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[ComQ]]-[[ComX]] {{PubMed|22878193}}
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| * '''[[Localization]]:'''
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| ** secreted (according to Swiss-Prot)
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| === Database entries ===
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P45453 P45453]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU31700]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[comQ]]-[[comX]]'' {{PubMed|1715859}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=comX_3255853_3256020_-1 comX] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|1715859}}
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| * '''Regulation:'''
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| * '''Regulatory mechanism:'''
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| The ComX --> surfactin signaling pathway is an example for paracrine signaling in bacteria
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| =References=
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| ==Reviews==
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| <pubmed> 22024380 </pubmed>
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| ==Original publications==
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| <pubmed>16407988,11133937,12067344,19202088,14679219,15564679,17240141,19605685, 1715859 22878193 24296669 22511326,21636272 </pubmed>
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| [[Category:Protein-coding genes]]
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