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| * '''Description:''' [[RNA polymerase]] sporulation-specific sigma factor ([[SigK]]) (C-terminal half), other part: ''[[spoIVCB]]''<br/><br/>
| | {{#bank: SpoIIIC}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''spoIIIC''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''sigK, spoIVD, spoIVE ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || [[RNA polymerase]] sporulation-specific sigma factor <br/>([[SigK]]) (C-terminal half)
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || late mother cell-specific gene expression
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU26390 spoIIIC]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/SpoIIIC SpoIIIC]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 16 kDa, 9.608
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 414 bp, 138 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yqaB]]'', ''[[yrkS]]''
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| |style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/spoIIIC_nucleotide.txt Gene sequence (+200bp) ]'''
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| |style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/spoIIIC_protein.txt Protein sequence]'''
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| |colspan="2" | '''Genetic context''' <br/> [[Image:spoIIIC_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=spoIIIC_2701338_2701754_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:spoIIIC_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU26390]]
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[transcription]]}},
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| {{SubtiWiki category|[[sigma factors and their control]]}},
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| {{SubtiWiki category|[[sporulation proteins]]}},
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| {{SubtiWiki category|[[membrane proteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[GerE regulon]]}},
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| {{SubtiWiki regulon|[[SigE regulon]]}},
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| {{SubtiWiki regulon|[[SigK regulon]]}},
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| {{SubtiWiki regulon|[[SpoIIID regulon]]}}
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| =The [[SigK regulon]]=
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU26390
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/spoIVCB-spoIIIC.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10919]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:'''
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[SigK]]-([[RpoB]]-[[RpoC]])
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| * '''[[Localization]]:'''
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| === Database entries ===
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P12254 P12254]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU26390]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[sigK]]'' (composed of ''[[spoIVCB]]-[[spoIIIC]]'') {{PubMed|2536191}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=spoIIIC_2701338_2701754_1 spoIIIC] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:''' [[SigE]] {{PubMed|15699190,2841290}}, [[SigK]] {{PubMed|2841290}}
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| * '''Regulation:'''
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| ** expressed during sporulation in the mother cell ([[SigE]], [[SigK]], [[GerE]], [[SpoIIID]]) {{PubMed|15699190,2841290,10075739,7966271}}
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| * '''Regulatory mechanism:'''
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| ** [[GerE]]: transcription repression {{PubMed|10075739}}
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| ** [[SpoIIID]]: transcription activation {{PubMed|7966271}}
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| * '''Additional information:'''
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| ** [[SigK]] is activated by processing of membrane-bound pro-[[SigK]] by the [[SpoIVFB]] metalloprotease {{PubMed|23585539,19805276}}
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| ** ''spoIVCB'' and ''[[spoIIIC]]'' form a composite gene in the mother cell during sporulation by excising the intervening DNA sequence.
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| ==The [[SigK regulon]]==
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| <pubmed>16385044,15383836,</pubmed>
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| ==Other original publications==
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| <pubmed>2163341,3114422,3125151,3121385,23585539,2536191, </pubmed>
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| [[Category:Protein-coding genes]]
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