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| * '''Description:''' antiadaptor protein, assembly link between regulatory components of the competence signal transduction pathway <br/><br/>
| | {{#bank: ComS}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''comS''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || antiadaptor protein (anti-[[MecA]])
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| |style="background:#ABCDEF;" align="center"|'''Function''' || control of [[ComK]] degradation
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU03500 comS]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/ComS ComS]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 5 kDa, 9.145
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 138 bp, 46 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[srfAB]]'', ''[[srfAC]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU03500 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU03500 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU03500 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:comS_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=comS_390880_391020_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:comS_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU03500]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[genetic competence]]}},
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| {{SubtiWiki category|[[short peptides]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[Abh regulon]]}},
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| {{SubtiWiki regulon|[[CodY regulon]]}},
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| {{SubtiWiki regulon|[[ComA regulon]]}},
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| {{SubtiWiki regulon|[[PerR regulon]]}},
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| {{SubtiWiki regulon|[[Spx regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU03500
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/srfAA-srfAB-comS-srfAC-srfAD.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11045]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:'''
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| **[[MecA]]-[[ComS]] [http://www.ncbi.nlm.nih.gov/sites/entrez/10447896 PubMed]
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| * '''[[Localization]]:'''
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| === Database entries ===
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P80355 P80355]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU03500]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[srfAA]]-[[srfAB]]-[[comS]]-[[srfAC]]-[[srfAD]]'' {{PubMed|1715856}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=comS_390880_391020_1 comS] {{PubMed|22383849}}
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| * '''Sigma factor:''' [[SigA]] {{PubMed|1715856}}
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| * '''Regulation:'''
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| ** repressed during growth in the presence of branched chain amino acids ([[CodY]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8830686 PubMed]
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| ** repressed during hydrogen peroxide stress ([[PerR]]) {{PubMed|16166527}}
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| ** expressed at high cell density ([[ComA]]) {{PubMed|16091051}}
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| * '''Regulatory mechanism:'''
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| ** [[CodY]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/8830686 PubMed]
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| ** [[ComA]]: transcription activation {{PubMed|1715856,16091051}}
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| ** [[PerR]]: transcription activation {{PubMed|16166527}}
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| ** [[Spx]]: transcription repression {{PubMed|12642660}}
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| ** [[Abh]]: transcription repression{{PubMed|20817675}}
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| ==Reviews==
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| <pubmed> 19609260</pubmed>
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| ==Original Publications==
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| <pubmed>17560370,10447896, 12642660,9000055, 10361283, 10447896, 11703662 1715856 16091051 20817675</pubmed>
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| [[Category:Protein-coding genes]]
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